N,N,3-三甲基苯甲酰胺合成路线 （共 9 条）
反应条件
LDBMOA in tetrahydrofuran; hexane T=0°C; 0.5 h;
参考文献
Kim, Yu Ri; An, Duk Keun
Bulletin of the Korean Chemical Society, 2012 , vol. 33, # 12 p. 4194 - 4196
反应条件
1: With diisobutylaluminium hydride in tetrahydrofuran; hexane T=-78°C; 1.5 h; Inert atmosphere; 2: With ammonia; iodine in tetrahydrofuran; hexane; water T=0 - 20°C; Inert atmosphere;
参考文献
Suzuki, Yusuke; Yoshino, Takumi; Moriyama, Katsuhiko; Togo, Hideo
Tetrahedron, 2011 , vol. 67, # 21 p. 3809 - 3814
反应条件
1: 1-bromo-3-methyl-benzene With n-butyllithium in tetrahydrofuran; hexane
T=-78°C; 0.5 h;
2: N,N-dimethyl-formamide in tetrahydrofuran; hexane
T=-78 - 20°C; 2 h;
3: methanol Further stages;
参考文献
Ushijima, Sousuke; Moriyama, Katsuhiko; Togo, Hideo
Tetrahedron, 2012 , vol. 68, # 24 p. 4701 - 4709
反应条件
1: meta-methylbenzoic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in dichloromethane
T=0 - 20°C; 1 h;
2: dimethylammonium chloride With N-ethyl-N,N-diisopropylamine in dichloromethane
T=0 - 20°C; 72 h;
参考文献
Ferring B.V.
Patent: EP1512687 A1, 2005 ;
Location in patent: Page/Page column 13 ;
反应条件
hydrogenchloride; tert.-butylhydroperoxide; iodine in cyclohexane; water
T=70 - 80°C; 20 h;
参考文献
Gao, Lingfeng; Tang, Haoming; Wang, Zhiyong
Chemical Communications, 2014 , vol. 50, # 31 p. 4085 - 4088
反应条件
tert.-butylhydroperoxide; iodine; sodium hydroxide
T=70 - 80°C; 24 h;
参考文献
Xu, Kun; Hu, Yanbin; Zhang, Sheng; Zha, Zhenggen; Wang, Zhiyong
Chemistry - A European Journal, 2012 , vol. 18, # 32 p. 9793 - 9797
反应条件
methanesulfonic acid; phosphorous pentoxide
T=70 - 90°C; 12 h;
参考文献
Kaboudin, Babak; Haghighat, Hamideh
Journal of the Iranian Chemical Society, 2012 , vol. 9, # 6 p. 951 - 955
反应条件
methanesulfonic acid; phosphorous pentoxide
T=70 - 90°C; 12 h;
参考文献
Kaboudin, Babak; Haghighat, Hamideh
Journal of the Iranian Chemical Society, 2012 , vol. 9, # 6 p. 951 - 955
反应条件
1: 12 h
2: H2O; benzene / 0.08 h / 5 °C
3: 87 percent / H2S / cyclohexane / 70 - 80 °C
View Scheme
参考文献
Kantlehner, Willi; Haug, Erwin; Farkas, Michael
Liebigs Annalen der Chemie, 1982 , # 8 p. 1582 - 1587
