4-氨基噻吩-3-羧酸甲酯合成路线 （共 11 条）
参考文献
LAILA NUTRACEUTICALS
Patent: US2010/68178 A1, 2010 ;
Location in patent: Page/Page column 17 ;
反应条件
thionyl chloride T=0°C; 24 h; Reflux;
参考文献
European Journal of Medicinal Chemistry, , vol. 76, p. 343 - 351
反应条件
hydrogen bromide; copper(I) bromide; sodium nitrite 1.) water, 0 deg C, 1 h, 2.) water, 60 deg C; Yield given. Multistep reaction;
参考文献
Corral, Carlos; Lasso, Ana; Lissavetzky, Jaime; Alvarez-Insua, Alberto Sanchez; Valdeolmillos, Ana M.
Heterocycles, 1985 , vol. 23, # 6 p. 1431 - 1435
反应条件
2: DMAP / acetonitrile 3: NaOMe / methanol 4: LiOH / tetrahydrofuran; H2O View Scheme
参考文献
Carroll, William A.; Zhang, Xiaolin
Tetrahedron Letters, 1997 , vol. 38, # 15 p. 2637 - 2640
反应条件
1: 1.) conc. HBr, NaNO2, 2.) conc. HBr, CuBr / 1.) water, 0 deg C, 1 h, 2.) water, 60 deg C 2: 100 percent / 1N NaOH / ethanol / 0.5 h / Heating View Scheme
参考文献
Corral, Carlos; Lasso, Ana; Lissavetzky, Jaime; Alvarez-Insua, Alberto Sanchez; Valdeolmillos, Ana M.
Heterocycles, 1985 , vol. 23, # 6 p. 1431 - 1435
反应条件
sodium carbonate in 1,4-dioxane; water T=0 - 20°C; 40 h;
参考文献
SCHERING CORPORATION
Patent: WO2009/58728 A1, 2009 ;
Location in patent: Page/Page column 76-77 ;
WO 2009/058728 A1
反应条件
2: DMAP / acetonitrile 3: NaOMe / methanol View Scheme
参考文献
Carroll, William A.; Zhang, Xiaolin
Tetrahedron Letters, 1997 , vol. 38, # 15 p. 2637 - 2640
反应条件
1: 1.) 6M HCl, NaNO2, 2.) conc. HCl, KI / 1.) water, 0 deg C, 1 h, 2.) water, 60 deg C
2: 100 percent / 1N NaOH / ethanol / 0.5 h / Heating
View Scheme
参考文献
Corral, Carlos; Lasso, Ana; Lissavetzky, Jaime; Alvarez-Insua, Alberto Sanchez; Valdeolmillos, Ana M.
Heterocycles, 1985 , vol. 23, # 6 p. 1431 - 1435
反应条件
formic acid; NaOAc·3H2O
参考文献
Agrevo UK Limited
Patent: US6432964 B1, 2002 ;
参考文献
Carroll, William A.; Zhang, Xiaolin
Tetrahedron Letters, 1997 , vol. 38, # 15 p. 2637 - 2640
