4-氨基丁酸乙酯.盐酸盐合成路线 （共 21 条）
反应条件
hydrogenchloride in ethyl acetate 3.5 h;
参考文献
Weitman, Michal; Lerman, Keti; Nudelman, Abraham; Major, Dan Thomas; Hizi, Amnon; Herschhorn, Alon
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 2 p. 447 - 467
参考文献
Chemische Berichte, , vol. 33, p. 2235
反应条件
water 10 h; Ambient temperature;
参考文献
Menezes, Royce; Smith, Michael B.
Synthetic Communications, 1988 , vol. 18, # 4 p. 1625 - 1636
反应条件
1: 96 percent / HCl gas / diethyl ether / 0.08 h 2: 88 percent / H2O / 10 h / Ambient temperature View Scheme
参考文献
Synthetic Communications, , vol. 18, # 4 p. 1625 - 1636
反应条件
sodium hydrogencarbonate in dichloromethane T=20°C; 1 h;
参考文献
Kim, In-Hae; Heirtzler, Fenton R.; Morisseau, Christophe; Nishi, Kosuke; Tsai, Hsing-Ju; Hammock, Bruce D.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 10 p. 3621 - 3629
反应条件
in toluene T=60 - 110°C; 2 h;
参考文献
Ozaki; Watanabe; Nagase; et al.
Chemical and Pharmaceutical Bulletin, 1986 , vol. 34, # 2 p. 893 - 896
反应条件
1: 4-aminobutyric acid ethyl ester hydrochloride With water; sodium hydroxide T=80°C; 4 h; 2: di-tert-butyl dicarbonate in 1,4-dioxane T=20°C; 4 h; 3: With hydrogenchloride in water pH=3;
参考文献
Conrig Pharma ApS; Hansen, John Bondo; Thomsen, Mikael Søndergaard
Patent: US2013/303497 A1, 2013 ;
Location in patent: Paragraph 0249-0252 ;
反应条件
sodium hydrogencarbonate in chloroform; water
参考文献
Floch,L.; Kovac,S.
Collection of Czechoslovak Chemical Communications, 1975 , vol. 40, p. 2845 - 2854
反应条件
potassium carbonate in tetrahydrofuran; water T=20°C; 4 h; Product distribution / selectivity;
参考文献
Conrig Pharma ApS; Hansen, John Bondo; Thomsen, Mikael Søndergaard
Patent: US2013/303497 A1, 2013 ;
Location in patent: Paragraph 0276-0277 ;
参考文献
Curtius; Mueller
Chemische Berichte, 1904 , vol. 37, p. 1265
