N,N-二异丙基-4-甲基苯甲酰胺合成路线 （共 7 条）
反应条件
sodium in tetrahydrofuran Ambient temperatureultrasonic bath;
参考文献
Karaman, Rafik; Fry, James L.
Tetrahedron Letters, 1990 , vol. 31, # 7 p. 941 - 944
反应条件
triethylamine in dichloromethane
T=20°C; Inert atmosphere;
参考文献
Schroeder, Nils; Wencel-Delord, Joanna; Glorius, Frank
Journal of the American Chemical Society, 2012 , vol. 134, # 20 p. 8298 - 8301
反应条件
n-butyllithium in diethyl ether; hexane
T=0°C; 2 h;
参考文献
Deka, Dibakar C.; Purkayastha, Biswajit; Paul, Maumita
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2003 , vol. 42, # 10 p. 2641 - 2642
反应条件
1: 4-methyl-benzoic acid With thionyl chloride
2: diisopropylamine With triethylamine in dichloromethane
参考文献
Baston, Eckhard; Salem, Ola I. A.; Hartmann, Rolf W.
Archiv der Pharmazie, 2003 , vol. 336, # 1 p. 31 - 38
反应条件
in tetrahydrofuran
T=20°C; 4 h;
参考文献
Katrizky, Alan R.; Salgado, Hector J.; Chermprapai, Amornsri; Ponkshe, Narayan K.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , p. 153 - 158
反应条件
1.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere
1.2: -50 - 20 °C / Inert atmosphere
2.1: hydrogenchloride; acetic acid / water / 24 h / Reflux; Inert atmosphere
View Scheme
参考文献
Yang, Guoqiang; Zhang, Wanbin
Organic Letters, 2012 , vol. 14, # 1 p. 268 - 271
反应条件
TPPBr2 in chloroform
T=-60°C; von Braun degradation; Reflux;
参考文献
Vaccari, Daniele; Davoli, Paolo; Spaggiari, Alberto; Prati, Fabio
Synlett, 2008 , # 9 p. 1317 - 1320
