2,6-二甲氧基-4-甲基苯甲醛合成路线 （共 17 条）
反应条件
1: 1,3-dimethoxy-5-methyl-benzene With n-butyllithium; N,N,N',N,-tetramethylethylenediamine in diethyl ether
3 h; Heating;
2: N,N-dimethyl-formamide in diethyl ether
T=20°C; 2 h;
参考文献
Trost, Barry M.; Shen, Hong C.; Dong, Li; Surivet, Jean-Philippe; Sylvain, Catherine
Journal of the American Chemical Society, 2004 , vol. 126, # 38 p. 11966 - 11983
反应条件
1: With n-butyllithium; N,N,N',N,-tetramethylethylenediamine in diethyl ether; hexane
3 h; RefluxInert atmosphere;
2: With N,N-dimethyl-formamide in diethyl ether; hexane
T=0 - 20°C; Inert atmosphere;
参考文献
Tietze, Lutz F.; Spiegl, Dirk A.; Stecker, Florian; Major, Julia; Raith, Christian; Grosse, Christian
Chemistry - A European Journal, 2008 , vol. 14, # 29 p. 8956 - 8963
反应条件
potassium carbonate in acetone
3 h; Heating;
参考文献
Srivastava, Vandana; Darokar, Mahendra P.; Fatima, Atiya; Kumar; Chowdhury, Chinmay; Saxena, Hari Om; Dwivedi, Gaurav R.; Shrivastava, Kunal; Gupta, Vivek; Chattopadhyay; Luqman, Suaib; Gupta; Negi, Arvind S.; Khanuja, Suman P.S.
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 1 p. 518 - 525
反应条件
1.1: K2CO3 / acetone
2.1: tetramethylene diamine; n-butyllithium / diethyl ether / 3 h / Heating
2.2: 97 percent / diethyl ether / 2 h / 20 °C
View Scheme
参考文献
Trost, Barry M.; Shen, Hong C.; Dong, Li; Surivet, Jean-Philippe; Sylvain, Catherine
Journal of the American Chemical Society, 2004 , vol. 126, # 38 p. 11966 - 11983
反应条件
trichlorophosphate
T=110°C; 1 h;
参考文献
Foti, Mario C.; Daquino, Carmelo; Mackie, Iain D.; DiLabio, Gino A.; Ingold
Journal of Organic Chemistry, 2008 , vol. 73, # 23 p. 9270 - 9282
反应条件
hydrogenchloride; chloroform; tin(ll) chloride
Reagens 4:Aether;und Erwaermen des Reaktionsprodukts mit waessr.Natriumacetat-Loesung auf dem Wasserbad;
参考文献
Robertson; Robinson
Journal of the Chemical Society, 1927 , p. 2204
反应条件
1: thionyl chloride
2: tin (II)-chloride; hydrogen chloride; chloroform / Reagens 4:Aether;und Erwaermen des Reaktionsprodukts mit waessr.Natriumacetat-Loesung auf dem Wasserbad
View Scheme
参考文献
Robertson; Robinson
Journal of the Chemical Society, 1927 , p. 2204
反应条件
1: benzene; ammonia
2: thionyl chloride
3: tin (II)-chloride; hydrogen chloride; chloroform / Reagens 4:Aether;und Erwaermen des Reaktionsprodukts mit waessr.Natriumacetat-Loesung auf dem Wasserbad
View Scheme
参考文献
Robertson; Robinson
Journal of the Chemical Society, 1927 , p. 2204
反应条件
potassium carbonate; acetone
参考文献
Leon et al.
Journal of the Chemical Society, 1931 , p. 2672,2686
反应条件
(i) nBuLi, THF, hexane, (ii) /BRN= 1098352/; Multistep reaction;
参考文献
Achenbach; Kohl; Kunze
Chemische Berichte, 1979 , vol. 112, # 5 p. 1841 - 1848
