1-(4-苯基-2-噻唑)-哌嗪合成路线 （共 4 条）
反应条件
hydrogenchloride; water in ethyl acetate
T=20°C; 4 h;
参考文献
Kono, Mitsunori; Matsumoto, Takahiro; Kawamura, Toru; Nishimura, Atsushi; Kiyota, Yoshihiro; Oki, Hideyuki; Miyazaki, Junichi; Igaki, Shigeru; Behnke, Craig A.; Shimojo, Masato; Kori, Masakuni
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 1 p. 28 - 41
反应条件
1: ethanol / 3 h / 80 °C
2: hydrogen bromide / acetic acid / 3 h / 130 °C
3: potassium carbonate / N,N-dimethyl-formamide / 8 h / 120 °C
4: hydrogenchloride; water / ethyl acetate / 4 h / 20 °C
View Scheme
参考文献
Kono, Mitsunori; Matsumoto, Takahiro; Kawamura, Toru; Nishimura, Atsushi; Kiyota, Yoshihiro; Oki, Hideyuki; Miyazaki, Junichi; Igaki, Shigeru; Behnke, Craig A.; Shimojo, Masato; Kori, Masakuni
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 1 p. 28 - 41
反应条件
1: hydrogen bromide / acetic acid / 3 h / 130 °C
2: potassium carbonate / N,N-dimethyl-formamide / 8 h / 120 °C
3: hydrogenchloride; water / ethyl acetate / 4 h / 20 °C
View Scheme
参考文献
Kono, Mitsunori; Matsumoto, Takahiro; Kawamura, Toru; Nishimura, Atsushi; Kiyota, Yoshihiro; Oki, Hideyuki; Miyazaki, Junichi; Igaki, Shigeru; Behnke, Craig A.; Shimojo, Masato; Kori, Masakuni
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 1 p. 28 - 41
反应条件
1: potassium carbonate / N,N-dimethyl-formamide / 8 h / 120 °C
2: hydrogenchloride; water / ethyl acetate / 4 h / 20 °C
View Scheme
参考文献
Kono, Mitsunori; Matsumoto, Takahiro; Kawamura, Toru; Nishimura, Atsushi; Kiyota, Yoshihiro; Oki, Hideyuki; Miyazaki, Junichi; Igaki, Shigeru; Behnke, Craig A.; Shimojo, Masato; Kori, Masakuni
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 1 p. 28 - 41
