4-溴-1,3-苯二甲酸合成路线 （共 16 条）
反应条件
Einleiten von Phosgen bei 130-155grad und Behandeln des Reaktionsprodukts mit wss. Salzsaeure;
参考文献
DE454477 , ;
DRP/DRBP Org.Chem.
反应条件
1: 90 percent / thionyl chloride / 24 h 2: 70 percent / cuprous oxide / N,N-dimethyl-acetamide / 20 h / 165 °C 3: 75 percent / aq. KOH / ethanol / 0.5 h / Heating 4: 80 percent / conc. H2SO4 / 18 h / 20 °C View Scheme
参考文献
Kottani, Rudresha; Majjigapu, Janaki R. R.; Kurchan, Alexei; Majjigapu, Kavitha; Gustafson, Tiffany P.; Kutateladze, Andrei G.
Journal of the American Chemical Society, 2006 , vol. 128, # 46 p. 14794 - 14795
反应条件
1: copper(I) oxide; copper; potassium carbonate / 2-ethoxy-ethanol / 0.75 h / 130 °C / Microwave irradiation; Inert atmosphere 2: thionyl chloride / 48 h / 20 °C / Inert atmosphere 3: palladium 10 on activated carbon; hydrogen / methanol / 10 h / 20 °C View Scheme
参考文献
Sosic, Izidor; Barreteau, Helne; Simcic, Mihael; Sink, Roman; Cesar, Jozko; Zega, Anamarija; Grdadolnik, Simona Golic; Contreras-Martel, Carlos; Dessen, Andrea; Amoroso, Ana; Joris, Bernard; Blanot, Didier; Gobec, Stanislav
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 7 p. 2880 - 2894
反应条件
water; sodium carbonate; N,N,N',N,-tetramethylethylenediamine; copper(I) bromide T=85°C; 18 h;
参考文献
LegoChem Biosciences, Inc.; CHO, Young Lag; YUN, Joung Yul; PARK, Chul Soon; CHAE, Sang Eun; LEE, Hyang Sook; OH, Kyuman; HEO, Hye Jin; KANG, Dae Hyuck; YANG, Young Jae; KWON, Hyun Jin; PARK, Tae Kyo; WOO, Sung Ho; KIM, Yong Zu
Patent: EP2706062 A2, 2014 ;
Location in patent: Paragraph 0141 ;
反应条件
sulfuric acid
Esterification; 12 h; Heating;
参考文献
Igarashi, Susumu; Kimura, Takenori; Naito, Ryo; Hara, Hiromu; Fujii, Masahiro; Koutoku, Hiroshi; Oritani, Hiroyuki; Mase, Toshiyasu
Chemical and Pharmaceutical Bulletin, 1999 , vol. 47, # 8 p. 1073 - 1080
反应条件
copper; potassium carbonate in N,N-dimethyl-formamide
12 h; Heating;
参考文献
Geertsema, Edzard M.; Schoevaars, Anne Marie; Meetsma, Auke; Feringa, Ben L.
Organic and Biomolecular Chemistry, 2006 , vol. 4, # 22 p. 4101 - 4112
