4-(2-羟基乙基)苯甲腈合成路线 （共 17 条）
反应条件
sodium tetrahydroborate in ethanol; dichloromethane T=20°C; 1 h;
参考文献
Chernyak, Natalia; Buchwald, Stephen L.
Journal of the American Chemical Society, 2012 , vol. 134, # 43 p. 18147 - 18147,1
反应条件
1.1: hydrogenchloride / water; acetone 1.2: 0.05 h / Sonication 2.1: sodium tetrahydroborate / ethanol; dichloromethane / 1 h / 20 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 134, # 30 p. 12466 - 12469
反应条件
1: 16.2 g / H2 / PtO2 / aq. ethanol 2: 1.) HCl, NaNO2; 2.) Cu2Cl2 / H2O / 1.) 3 deg C; 2.) 3-50 deg C, 4 h View Scheme
参考文献
Helvetica Chimica Acta, , vol. 64, # 5 p. 1688 - 1703
反应条件
1: 1.) H2SO4, HNO3; 2.) HCl / 1.) acetic anhydride, -15 deg C, 105 min; 2.) methanol, reflux, 3.5 h 2: 16.2 g / H2 / PtO2 / aq. ethanol 3: 1.) HCl, NaNO2; 2.) Cu2Cl2 / H2O / 1.) 3 deg C; 2.) 3-50 deg C, 4 h View Scheme
参考文献
Helvetica Chimica Acta, , vol. 64, # 5 p. 1688 - 1703
反应条件
HNO2 Multistep reaction;
参考文献
Journal of the American Chemical Society, , vol. 104, # 7 p. 1937 - 1951
反应条件
1: Et3N / CH2Cl2 / ice-cooling 2: 31 percent / AIBN; Bu3SnH / benzene / 12 h / Heating View Scheme
参考文献
Organic and Biomolecular Chemistry, , vol. 1, # 14 p. 2499 - 2505
反应条件
Cu2Cl2; hydrogenchloride; sodium nitrite in water 1.) 3 deg C; 2.) 3-50 deg C, 4 h; Yield given;
参考文献
Helvetica Chimica Acta, , vol. 64, # 5 p. 1688 - 1703
反应条件
hydrogenchloride; sodium cyanide; sodium nitrite 1.) H2O, 0-5 deg C; 2.) benzene, 0-5 deg C, 30 min; room temp., 4 h; Yield given. Multistep reaction;
参考文献
Pharmazie, , vol. 37, # 1 p. 13 - 16
反应条件
Jone's reagent in acetone T=20°C; 0.166667 h;
参考文献
DAIICHI PHARMACEUTICAL CO., LTD.
Patent: EP1612204 A1, 2006 ;
Location in patent: Page/Page column 46 ;
反应条件
phosphorus tribromide in chloroform 1.5 h; Heating;
参考文献
Wagner, G.; Vieweg, H.
Pharmazie, 1982 , vol. 37, # 1 p. 13 - 16
