四氢-2H-吡喃-2-醇合成路线 （共 136 条）
反应条件
1: 1.) n-BuLi / 1.) hexane, THF, 0 deg C, 30 min, 2.) THF, RT, 20 h 2: DMSO, oxalyl chloride / tetrahydrofuran / 0.33 h / -70 °C 3: 1.) t-BuLi / 1.) hexane, THF, 0 deg C, 1 h, 2.) THF, hexane, RT, 20 h View Scheme
参考文献
Moeller, Kevin D.; Tinao, Luzviminda V.
Journal of the American Chemical Society, 1992 , vol. 114, # 3 p. 1033 - 1041
反应条件
1: KMnO4; natrium carbonate / Hydrogenation.das Salz der 5-Hydroxy-valeriansaeure entsteht 2: concentrated H2SO4; HBr View Scheme
参考文献
Gaudry; Berlinguet
Canadian Journal of Research, Section B: Chemical Sciences, 1949 , vol. 27, p. 287
反应条件
nickel T=116°C; P=36775.4 - 51485.6 Torr; Hydrogenation;
参考文献
Sharples Chem.Inc.
Patent: US2516337 , 1946 ;
反应条件
1: potassium carbonate 2: Raney nickel; ethanol / Hydrogenation View Scheme
参考文献
Glacet; Gaumeton
Bulletin de la Societe Chimique de France, 1955 , p. 225,227
反应条件
1: benzene 2: H2 / Pd-C / ethanol 3: CBr4, PPh3 / acetonitrile View Scheme
参考文献
Tetrahedron Letters, , vol. 33, # 51 p. 7973 - 7976
反应条件
triphenylphosphine; diethylazodicarboxylate in tetrahydrofuran T=20°C; Mitsunobu reaction; 2 h;
参考文献
Azzouz, Rabah; Bischoff, Laurent; Fouquet, Marc-Henri; Marsais, Francis
Synlett, 2005 , # 18 art. no. D17805ST, p. 2808 - 2810
反应条件
1: in diethyl ether 1 h; Inert atmosphere; 2: With hydrogenchloride in water pH=4 - 5;
参考文献
UNIVERSITY OF AKRON RESEARCH FOUNDATION
Patent: US2012/116098 A1, 2012 ;
Location in patent: Page/Page column 4 ;
反应条件
in dichloromethane
48 h; Ambient temperature; Yield given. Yields of byproduct given;
参考文献
Luxenburger, Andreas
Tetrahedron, 2003 , vol. 59, # 18 p. 3297 - 3305
反应条件
in tetrahydrofuran
Wittig reaction; 24 h; RefluxInert atmosphere;
参考文献
Petrignet, Julien; Boudhar, Aicha; Blond, Gaelle; Suffert, Jean
Angewandte Chemie - International Edition, 2011 , vol. 50, # 14 p. 3285 - 3289
反应条件
(i) DMF, (ii) aq. KOH, (iii) /BRN= 102415/, Et2O; Multistep reaction;
参考文献
Bergel'son,L.D. et al.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1963 , p. 454 - 456
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1963 , p. 506 - 509
