4-羟基-1,7-二甲基-2-氧代-1,2-二氢-1,8-萘啶-3-羧酸乙酯合成路线 （共 6 条）
反应条件
sodium; methylamine in methanol; diethyl ether; ethanol; water
反应条件
1: 70 percent / 5 h / 60 °C / steel vessel 2: aq. NaOH; ethanol / 18 h / Heating 3: 51 percent / H2O; benzene / 2 h 4: 1) NaH / 1) dimethylacetamide, 2) 120 deg C, 18 h View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 22, p. 193 - 206
反应条件
1: aq. NaOH; ethanol / 18 h / Heating 2: 51 percent / H2O; benzene / 2 h 3: 1) NaH / 1) dimethylacetamide, 2) 120 deg C, 18 h View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 22, p. 193 - 206
反应条件
1: 51 percent / H2O; benzene / 2 h 2: 1) NaH / 1) dimethylacetamide, 2) 120 deg C, 18 h View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 22, p. 193 - 206
反应条件
ethanol; sodium 1.) Et2O, RT, 1 h, 2.) warming, 5 min; Yield given. Multistep reaction;
参考文献
Journal of Medicinal Chemistry, , vol. 30, # 12 p. 2270 - 2277
反应条件
sodium hydride 1) dimethylacetamide, 2) 120 deg C, 18 h; Yield given. Multistep reaction;
参考文献
Journal of Heterocyclic Chemistry, , vol. 22, p. 193 - 206
