3-氯-5-(三氟甲基)苯胺合成路线 （共 2 条）
反应条件
tin(ll) chloride in ethyl acetate 3 h; Heating / reflux;
参考文献
BRISTOL-MYERS SQUIBB COMPANY
Patent: WO2009/3077 A1, 2008 ;
Location in patent: Page/Page column 135 ;
反应条件
1: With hydrogenchloride; acetic acid; sodium nitrite in water T=0°C; 1 h; 2: With sulfur dioxide in water; acetic acid T=0 - 20°C; 1 h;
参考文献
CONVERGENCE PHARMACEUTICALS LIMTED; Gleave, Robert James; Hachisu, Shuji; Page, Lee William
Patent: US2013/116270 A1, 2013 ;
Location in patent: Paragraph 0115; 0116; 0117 ;
