1: in tetrahydrofuran T=20°C; 0.5 h; Inert atmosphere; 2: With phosphonic acid diethyl ester in tetrahydrofuran T=20°C; Inert atmosphere;

orthosilicic acid tetramethyl ester; n-octyltriethoxysilane; sodium lauryl sulfate; palladium diacetate; potassium carbonate in methanol; ethanol; water; butan-1-ol T=80°C; Heck reaction;

1,3,5,7-tetra-azatricyclo[5.1.1.13,5]decane; dnpf; bis(dibenzylideneacetone)-palladium(0) in N,N-dimethyl acetamide T=80°C; Heck Reaction; 20 h; Inert atmosphere; Overall yield = 74 percent; Overall yield = 85 mg;

1: pyridine / dichloromethane / 12 h / 0 - 20 °C / |Schlenk technique; |Inert atmosphere 2: bis(dibenzylideneacetone)-palladium(0); 1,3,5,7-tetra-azatricyclo[5.1.1.13,5]decane; dnpf / N,N-dimethyl acetamide / 20 h / 80 °C / |Inert atmosphere View Scheme

(i) Mg, Et2O, (ii) /BRN= 386014/; Multistep reaction;