2-溴-5-硝基苯甲酸甲酯合成路线 （共 25 条）
反应条件
thionyl chloride T=0 - 20°C;
参考文献
Kawabata, Takeo; Jiang, Changsheng; Hayashi, Kazuhiro; Tsubaki, Kazunori; Yoshimura, Tomoyuki; et al.
Journal of the American Chemical Society, 2009 , vol. 131, p. 54 - 55
反应条件
sulfuric acid; nitric acid in water
参考文献
US6894174 B1, ;
Page/Page column 15 ;
反应条件
in methanol; diethyl ether; toluene 2 h; Inert atmosphereSchlenk technique;
参考文献
Dydio, Pawel; Reek, Joost N. H.
Angewandte Chemie - International Edition, 2013 , vol. 52, # 14 p. 3878 - 3882
Angew. Chem., 2013 , vol. 125, # 14 p. 4132
反应条件
1.1: t-BuLi / diethyl ether; pentane / 1 h / -78 °C 1.2: ZnCl2 / tetrahydrofuran / 1 h 1.3: 70 percent / Pd(dba)2; dppf / tetrahydrofuran / 18 h / 20 °C 2.1: 86 percent / LiBH4 / diethyl ether; methanol; tetrahydrofuran / 0 - 20 °C 3.1: 76 percent / PPA; MeSO3H / CHCl3 / Heating View Scheme
参考文献
Klein; Boche
Synthesis, 1999 , # 7 p. 1246 - 1250
反应条件
1: LiBH4 / diethyl ether 2: Pd(OAc)2; Tol3P / dioxane 3: polyphosphoric acid / 110 °C View Scheme
参考文献
Greenfield, Alexander; Grosanu, Cristina; Dunlop, John; McIlvain, Beal; Carrick, Tikva; Jow, Brian; Lu, Qiang; Kowal, Dianne; Williams, John; Butera, John
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 22 p. 4985 - 4988
反应条件
1: copper powder / 180 - 220 °C 2: concentrated sulfuric acid; water View Scheme
参考文献
Ullmann; Bielecki
Chemische Berichte, 1901 , vol. 34, p. 2176
反应条件
copper T=180 - 220°C;
参考文献
Shayda Technologies, Inc.
Patent: US6894174 B1, 2005 ;
Location in patent: Page/Page column 15 ;
反应条件
iron; ammonium chloride in methanol; water T=70°C; 1.75 h;
参考文献
Chin, Elbert; Li, Jim; Lui, Albert Sui-Ting; Talamas, Francisco Xavier
Patent: US2010/297073 A1, 2010 ;
Location in patent: Page/Page column 20 ;
反应条件
hydrogenchloride; potassium hydrogencarbonate in methanol
参考文献
Das, Jagabndhu; Barrish, Joel C.; Wityak, John
Patent: US2002/123484 A1, 2002 ;
US 20020123484 A1
反应条件
1: LiBH4 / diethyl ether 2: Pd(OAc)2; Tol3P / dioxane 3: polyphosphoric acid / 110 °C 4: H2 / PtO2 / methanol; tetrahydrofuran View Scheme
参考文献
Greenfield, Alexander; Grosanu, Cristina; Dunlop, John; McIlvain, Beal; Carrick, Tikva; Jow, Brian; Lu, Qiang; Kowal, Dianne; Williams, John; Butera, John
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 22 p. 4985 - 4988
