2-溴-5-硝基苯甲酸甲酯合成路线 （共 25 条）
反应条件
1: LiBH4 / diethyl ether
2: Pd(OAc)2; Tol3P / dioxane
3: polyphosphoric acid / 110 °C
View Scheme
参考文献
Greenfield, Alexander; Grosanu, Cristina; Dunlop, John; McIlvain, Beal; Carrick, Tikva; Jow, Brian; Lu, Qiang; Kowal, Dianne; Williams, John; Butera, John
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 22 p. 4985 - 4988
反应条件
1.1: t-BuLi / diethyl ether; pentane / 1 h / -78 °C
1.2: ZnCl2 / tetrahydrofuran / 1 h
1.3: 73 percent / Pd(dba)2; dppf / tetrahydrofuran / 18 h / 20 °C
2.1: 99 percent / LiBH4 / diethyl ether; methanol; tetrahydrofuran / 0 - 20 °C
3.1: 72 percent / PPA; MeSO3H / CHCl3 / Heating
View Scheme
参考文献
Klein; Boche
Synthesis, 1999 , # 7 p. 1246 - 1250
反应条件
1: tris(dibenzylideneacetone)dipalladium(0) chloroform complex; 2,2'-bis-(diphenylphosphino)-1,1'- binaphthyl; caesium carbonate / 20 - 130 °C
2: lithium hydroxide hydrate; water / methanol; tetrahydrofuran / |Reflux
View Scheme
参考文献
Oh, Soo-Jin; Hwang, Seok Jin; Jung, Jonghoon; Yu, Kuai; Kim, Jeongyeon; Choi, Jung Yoon; Hartzell, H. Criss; Roh, Eun Joo; Justin Lee
Molecular Pharmacology, 2013 , vol. 84, # 5 p. 726 - 735
反应条件
T=180°C; Erwaermen des jeweiligen Reaktionsprodukts mit Schwefelsaeure;
参考文献
Rule; Smith
Journal of the Chemical Society, 1937 , p. 1096,1101
反应条件
1: tris(dibenzylideneacetone)dipalladium(0) chloroform complex; 2,2'-bis-(diphenylphosphino)-1,1'- binaphthyl; caesium carbonate / 20 - 130 °C
2: lithium hydroxide hydrate; water / methanol; tetrahydrofuran / |Reflux
View Scheme
参考文献
Oh, Soo-Jin; Hwang, Seok Jin; Jung, Jonghoon; Yu, Kuai; Kim, Jeongyeon; Choi, Jung Yoon; Hartzell, H. Criss; Roh, Eun Joo; Justin Lee
Molecular Pharmacology, 2013 , vol. 84, # 5 p. 726 - 735
