3,4-二氢-6-甲基异喹啉合成路线 (共 5 条)
反应条件
manganese(IV) oxide in dichloromethane
4 h;
参考文献
BRISTOL-MYERS SQUIBB COMPANY; ORWAT, Michael J.; PINTO, Donald J.P.; SMITH II, Leon M.; SRIVASTAVA, Shefali; CORTE, James R.
Patent: WO2013/55984 A1, 2013 ;
Location in patent: Paragraph 00299 ;
反应条件
polyphosphoric acid (83percent P2O5)
T=145°C;
参考文献
Pitea, Demetrio; Beltrame, Pier Luigi; Ferrazza, Alberto; Todeschini, Roberto; Favini, Giorgio
Gazzetta Chimica Italiana, 1984 , vol. 114, # 1/2 p. 35 - 40
反应条件
2: POCl3 / 1,2,3,4-tetrahydro-naphthalene
View Scheme
参考文献
Augelli-Szafran, Corinne E.; Jaen, Juan C.; Moreland, David W.; Nelson, Carrie B.; Penvose-Yi, Jan R.; Schwarz, Roy D.
Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 15 p. 1991 - 1996
反应条件
1: 60 percent / LiAlH4 / diethyl ether
2: toluene / 70 - 80 °C
3: polyphosphoric acid (83percent P2O5) / 145 °C
View Scheme
参考文献
Pitea, Demetrio; Beltrame, Pier Luigi; Ferrazza, Alberto; Todeschini, Roberto; Favini, Giorgio
Gazzetta Chimica Italiana, 1984 , vol. 114, # 1/2 p. 35 - 40
反应条件
1: platinum on carbon; hydrogen / ethanol / 24 h / 2844.39 Torr
2: manganese(IV) oxide / dichloromethane / 4 h
View Scheme
参考文献
BRISTOL-MYERS SQUIBB COMPANY; ORWAT, Michael J.; PINTO, Donald J.P.; SMITH II, Leon M.; SRIVASTAVA, Shefali; CORTE, James R.
Patent: WO2013/55984 A1, 2013 ;