6-甲基-2-氧代-1-[3-(三氟甲基)苯基]-1,2-二氢吡啶-3-羧酸合成路线 （共 3 条）
反应条件
1: With sodium methylate in ethanol
2 h; Heating / reflux;
2: With sodium hydroxide; water
T=20°C;
参考文献
ASTRAZENECA AB
Patent: WO2007/129962 A1, 2007 ;
Location in patent: Page/Page column 50 ;
WO 2007/129962 A1
反应条件
1: With sodium methylate in methanol; ethanol
T=50 - 55°C; Industry scale;
2: With water; sodium hydroxide in methanol; ethanol
1 h; Industry scale;
3: With hydrogenchloride in methanol; ethanol; water
pH=2; Industry scale; Product distribution / selectivity;
参考文献
AstraZeneca AB
Patent: US2011/82155 A1, 2011 ;
Location in patent: Page/Page column 23 ;
US 20110082155 A1
反应条件
1: sodium hydrogencarbonate / isopropanol acetate / -10 - 10 °C
2: sodium methylate / ethanol; methanol / 50 - 55 °C
View Scheme
参考文献
AstraZeneca AB
Patent: US2011/82155 A1, 2011 ;
US 20110082155 A1
