1: 4-amino-2-trifluoromethylbenzaldehyde With hydrogenchloride in water; ethyl acetate; toluene T=20 - 25°C; 0.0833333 h; 2: 1-methyl-piperazine With pyridinium p-toluenesulfonate in ethyl acetate T=76 - 78°C; 3: With sodium tris(acetoxy)borohydride in ethyl acetate

1: With dimethylsulfide borane complex in tetrahydrofuran T=0°C; Reflux; 2: With hydrogenchloride in tetrahydrofuran; water T=20°C; 3: With sodium hydroxide in tetrahydrofuran; water T=0°C;

potassium carbonate in methanol; water 1 h;

1: potassium carbonate / dichloromethane / 3 h / 20 °C 2: palladium 10 on activated carbon; hydrogen / ethanol View Scheme

1: N-bromosuccinmide; 2,2'-azo-bisisobutyronitrile / 1,2-dichloro-ethane / 90 °C 2: potassium carbonate / dichloromethane / 3 h / 20 °C 3: palladium 10 on activated carbon; hydrogen / ethanol View Scheme

1: dichloromethane / 1 h 2: raney nickel (catcart) / methanol / 40 °C View Scheme

1.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 0.08 h / |Inert atmosphere; |Large scale 2.1: hydrogenchloride / toluene; ethyl acetate; water / 0.08 h / 20 - 25 °C 2.2: 76 - 78 °C View Scheme