2-氨基-5-溴-3-硝基吡啶合成路线 （共 37 条）
反应条件
sodium borohydride in ethyl acetate
参考文献
Sankyo Company, Limited
Patent: US5624935 A1, 1997 ;
反应条件
hydrazine hydrate; Ru-carbon in ethanol 3 h; Heating;
参考文献
Fray, M. Jonathan; Bull, David J.; Cooper, Kelvin; Parry, M. John; Stefaniak, Mark H.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 18 p. 3524 - 3535
反应条件
hydrazine in methanol; ethyl acetate
参考文献
Merck and Co., Inc.
Patent: US6025366 A1, 2000 ;
US 6025366 A
反应条件
in sodium hydroxide; ethanol
参考文献
Affinium Pharmaceuticals, Inc.
Patent: EP1226138 B1, 2004 ;
反应条件
1: sulfuric acid; sodium nitrite; water 2: bromine; phosphorus (III)-bromide / 100 °C 3: iron-turnings; acetic acid / 100 °C View Scheme
参考文献
Berrie et al.
Journal of the Chemical Society, 1952 , p. 2042,2044
反应条件
sulfuric acid; zinc in methanol; water T=90°C; 48 h;
参考文献
Epa, Kanishka; Aakeroey, Christer B.; Desper, John; Rayat, Sundeep; Chandra, Kusum Lata; Cruz-Cabeza, Aurora J.
Chemical Communications, 2013 , vol. 49, # 72 p. 7929 - 7931
反应条件
sodium carbonate; tetrakis(triphenylphosphine) palladium(0) in ethylene glycol dimethyl ether; water 5 h; RefluxInert atmosphere;
参考文献
Iwata, Hidehisa; Kohara, Yasuhisa; Cao, Sheldon X.; Guntupalli, Prasuna; Gwaltney, Stephen L.; Hosfield, David J.; Liu, Yan; Stafford, Jeffrey A.; Throop, Beverly
Patent: US2010/69431 A1, 2010 ;
Location in patent: Page/Page column 24 ;
反应条件
1: concentrated aqueous hydrochloric acid / -10 °C / Behandeln des Reaktionsgemisches mit wss. Natriumnitrit-Loesung 2: iron-turnings; acetic acid 3: sodium nitrite; aqueous hydrochloric acid; copper-powder / Diazotization View Scheme
参考文献
Berrie et al.
Journal of the Chemical Society, 1952 , p. 2042,2044
反应条件
iron; ytterbium(III) triflate T=75°C; 3 h;
参考文献
Wang, Fen; Tran-Dube, Michelle; Scales, Stephanie; Johnson, Sarah; McAlpine, Indrawan; Ninkovic, Sacha
Tetrahedron Letters, 2013 , vol. 54, # 31 p. 4054 - 4057
反应条件
1: NaNO2 / H2SO4 / 0 °C 2: hydrazine hydrate / Raney-Nickel / methanol / 2 h / 40 °C View Scheme
参考文献
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, , vol. 38, # 9 p. 1036 - 1040
