2-氨基-5-溴-3-硝基吡啶合成路线 （共 37 条）
反应条件
1: 36 percent / tBuNO; CuCl2 / acetonitrile / 2 h / Heating 2: 87 percent / SnCl2*2H2O / ethyl acetate / 3 h / Heating View Scheme
参考文献
Berrie et al.
Journal of the Chemical Society, 1952 , p. 2042,2044
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2007/129044 A1, 2007 ;
Location in patent: Page/Page column 77 ;
WO 2007/129044 A1
反应条件
tert.-butylnitrite in acetonitrile T=60°C; 2 h;
参考文献
WO2004/55003 A1, ;
Page 65-66 ;
WO 2004/055003 A1
反应条件
1: sulfuric acid; sodium nitrite; water 2: bromine; phosphorus (III)-bromide / 100 °C View Scheme
参考文献
Journal of the Chemical Society, , p. 2042,2044
反应条件
1: sulfuric acid; sodium nitrite; water 2: bromine; phosphorus (III)-bromide / 100 °C 3: iron-turnings; acetic acid / 100 °C 4: CuCN / 150 °C View Scheme
参考文献
Berrie et al.
Journal of the Chemical Society, 1952 , p. 2042,2044
反应条件
in 1-methyl-pyrrolidin-2-one T=80°C;
参考文献
UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL
Patent: US2008/125358 A1, 2008 ;
Location in patent: Page/Page column 17 ;
反应条件
potassium permanganate; ammonia T=-33°C; 5 h;
参考文献
Wozniak, Marian; Baranski, Andrzej; Szpakiewicz, Barbara
Liebigs Annalen der Chemie, 1991 , # 9 p. 875 - 878
反应条件
potassium permanganate T=-7°C; 0.5 h;
参考文献
Szpakiewicz, Barbara; Wozniak, Marian
Advanced Synthesis and Catalysis, 1999 , vol. 341, # 1 p. 75 - 78
反应条件
potassium permanganate; methylamine T=-7°C; 0.5 h;
参考文献
Szpakiewicz, Barbara; Wozniak, Marian
Advanced Synthesis and Catalysis, 1999 , vol. 341, # 1 p. 75 - 78
反应条件
sulfuric acid; sodium nitrite in water T=0 - 20°C; Inert atmosphere;
参考文献
Sapegin, Alexander V.; Kalinin, Stanislav A.; Smirnov, Alexey V.; Dorogov, Mikhail V.; Krasavin, Mikhail
Tetrahedron, 2014 , vol. 70, # 5 p. 1077 - 1083
