反应条件
1: 1.) NaH / 1.) THF, hexane, from -30 deg C to 0 deg C, 1 h, 2.) THF, 0 deg C, 2 h 2: 92 percent / H2, (PPh3)3RhCl / ethanol; benzene / 48 h / 3800 Torr / Ambient temperature 3: 69.5 percent / H2O, phosphate buffer pH=7, pig panereatic lipase, aq. NaOH / diisopropyl ether / 4.33 h / 20 °C 4: CF3COOH / CH2Cl2 / 1.) 0 deg C, 1 h, 2.) RT, 2 h View Scheme
参考文献
Banfi, Luca; Basso, Andrea; Guanti, Giuseppe; Zannetti, Maria Teresa
Tetrahedron Asymmetry, 1997 , vol. 8, # 24 p. 4079 - 4088
