3-乙酰胺基-4甲基苯甲酸合成路线 （共 14 条）
反应条件
1: With nitric acid T=-5 - 0°C; 1.75 h; 2: With water T=0°C; 0.5 h; 3: With acetic acid T=65°C; 1 h;
参考文献
AMGEN INC.
Patent: WO2007/76092 A2, 2007 ;
Location in patent: Page/Page column 71 ;
WO 2007/076092 A2
反应条件
nitric acid T=0°C; Nitration;
参考文献
Clews, John; Curtis, Anthony D.M.; Malkin, Hugh
Tetrahedron, 2000 , vol. 56, # 44 p. 8735 - 8746
反应条件
hydrogenchloride T=110°C; im Rohr;
参考文献
Chem. Zentralbl., , vol. 83, # I p. 136
反应条件
nitric acid
T=0°C; Nitration;
参考文献
Clews, John; Curtis, Anthony D.M.; Malkin, Hugh
Tetrahedron, 2000 , vol. 56, # 44 p. 8735 - 8746
