3-(甲硫基)-5-(4-溴苯基)-1,2,4-三嗪合成路线 （共 3 条）
反应条件
sodium hydrogencarbonate in ethanol; water
2 h; Reflux; regioselective reaction;
参考文献
Lv, Wei; Banerjee, Biplab; Molland, Katrina L.; Seleem, Mohamed N.; Ghafoor, Adil; Hamed, Maha I.; Wan, Baojie; Franzblau, Scott G.; Mesecar, Andrew D.; Cushman, Mark
Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 1 p. 406 - 418
反应条件
1: selenium(IV) oxide / 1,4-dioxane; water / 5 h / |Reflux
2: sodium hydrogencarbonate / water; ethanol / 2 h / |Reflux
View Scheme
参考文献
Lv, Wei; Banerjee, Biplab; Molland, Katrina L.; Seleem, Mohamed N.; Ghafoor, Adil; Hamed, Maha I.; Wan, Baojie; Franzblau, Scott G.; Mesecar, Andrew D.; Cushman, Mark
Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 1 p. 406 - 418
反应条件
hydrogen bromide; sodium hydrogencarbonate
1.) DMSO, 55 deg C, 6 h, 2.) DMSO, H2O, RT, 24 h; Yield given. Multistep reaction;
参考文献
McLean, Gillian A.; Royles, Brodyck J. L.; Smith, David M.; Bruce, Michael J.
Journal of Chemical Research, Miniprint, 1996 , # 10 p. 2623 - 2639
