3-溴-4,5-二甲氧基苯甲醛合成路线 （共 42 条）
反应条件
potassium carbonate in N,N-dimethyl-formamide T=50°C;
参考文献
Nakanishi; Suzuki
Organic letters, 1999 , vol. 1, # 7 p. 985 - 988
反应条件
1: 3-methoxy-4-hydroxy-5-bromo-benzaldehyde With potassium carbonate in acetone Inert atmosphere; 2: dimethyl sulfate in acetone T=25°C; 8 h; Inert atmosphere;
参考文献
Tadross, Pamela M.; Gilmore, Christopher D.; Bugga, Pradeep; Virgil, Scott C.; Stoltz, Brian M.
Organic Letters, 2010 , vol. 12, # 6 p. 1224 - 1227
反应条件
1: 72 percent / Br2, AcOH / 12 h / Ambient temperature 2: 70 percent / K2CO3 / dimethylformamide / 72 h / Ambient temperature View Scheme
参考文献
Journal of Antibiotics, , vol. 46, # 9 p. 1458 - 1470
反应条件
N-bromosuccinmide T=27°C; Solid phase reaction; bromination; 0.0333333 h;
参考文献
Sarma, Jagarlapudi A.R.P.; Nagaraju, Akula; Majumdar, Kanak K.; Samuel, Purnima M.; Das, Indira; Roy, Sujit; McGhie, Alistair J.
Journal of the Chemical Society. Perkin Transactions 2, 2000 , # 6 p. 1119 - 1123
反应条件
sodium hydroxide 2 h; Reflux;
参考文献
Mao, Jin-Long; Ran, Xiang-Kai; Tian, Jing-Zhen; Jiao, Bo; Zhou, Hong-Lei; Chen, Li; Wang, Zhen-Guo
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 5 p. 1549 - 1553
反应条件
1: 3,4-dihydroxy-benzaldehyde With bromine in chloroform 2: dimethyl sulfate With potassium carbonate in N,N-dimethyl-formamide Further stages.;
参考文献
Tetrahedron Letters, , vol. 49, # 36 p. 5309 - 5311
参考文献
Journal of the American Chemical Society, , vol. 51, p. 2194
参考文献
Justus Liebigs Annalen der Chemie, , vol. 391, p. 44
参考文献
Justus Liebigs Annalen der Chemie, , vol. 391, p. 44
反应条件
1: 1.) t-BuOK / 1.) THF, RT, 40 min, 2.) from -60 deg C to RT, 6 h 2: 1.) n-BuLi / 1.) hexane, THF, -78 deg C, 15 min, 2.) from -78 deg C to RT 3: oxalyl chloride, DMF / benzene / 1 h / Ambient temperature View Scheme
参考文献
Patten; Nguyen; Danishefsky
Journal of Organic Chemistry, 1988 , vol. 53, # 5 p. 1003 - 1007
