2-氨基-4-甲基吡啶合成路线 （共 193 条）
参考文献
Elghamry, Ibrahim
Synthetic Communications, 2009 , vol. 39, # 17 p. 3010 - 3015
反应条件
1: 1.) hydrogen chloride gas; 2.) sodium nitrite / 1.) concd. hydrochloric acid, 0 - 5 deg C; 2.) water 2: 90 percent / methanol / Heating 3: 1.) sodamide / 1.) liq. NH3, 30 min; 2.) liq. NH3, 3.5 h View Scheme
参考文献
Adger, Brian M.; Ayrey, Peter; Bannister, Robin; Forth, Michael A.; Hajikarimian, Yousef; et al.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1988 , p. 2791 - 2796
反应条件
1: 1.) hydrogen chloride gas; 2.) sodium nitrite / 1.) concd. hydrochloric acid, 0 - 5 deg C; 2.) water 2: 1.) 57percent sodium hydride in oil / 1.) DMF, r.t., 1 h; 2.) DMF, 75 - 80 deg C, 1 h View Scheme
参考文献
Lott; Shaw
Journal of the American Chemical Society, 1949 , vol. 71, p. 70,73
反应条件
1: potassium permanganate 2: HCl 3: lithium aluminum hydride View Scheme
参考文献
Feng, Dennis; Fisher, Michael; Liang, Gui-Bai; Qian, Xiaoxia; Brown, Chris; Gurnett, Anne; Leavitt, Penny Sue; Liberator, Paul A.; Mathew, John; Misura, Andrew; Samaras, Samantha; Tamas, Tamas; Schmatz, Dennis M.; Wyvratt, Matthew; Biftu, Tesfaye
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 23 p. 5978 - 5981
反应条件
1: With sulfuric acid; sodium nitrite in water T=0 - 95°C; 2.25 h; 2: With sodium hydroxide in water T=20°C; pH=6 - 7;
参考文献
AB SCIENCE; BENJAHAD, Abdellah; MOUSSY, Alain; CHEVENIER, Emmanuel; PICOUL, Willy; LERMET, Anne; PEZ, Didier; MARTIN, Jason; SANDRINELLI, Franck
Patent: WO2013/14170 A1, 2013 ;
Location in patent: Page/Page column 77-78 ;
WO 2013/014170 A1
反应条件
1: potassium permanganate 2: HCl View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 23 p. 5978 - 5981
反应条件
1: 51 percent / NaNO2, HBF4 / 0 deg C to rt 2: 26 percent / KMnO4 / H2O / Heating 3: 1) NEt3, ethyl chloroformate, 2) LiAlH4 / 1) benzene, rt, 1 h, 2) THF, -78 deg C, 30 min 4: 51 percent / DMSO, N,N'-dicyclohexylcarbodiimide, H3PO4 / 1.5 h / Ambient temperature View Scheme
参考文献
Ashimori; Ono; Uchida; Ohtaki; Fukaya; Watanabe; Yokoyama
Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 9 p. 2446 - 2458
反应条件
1.1: 48percent HBr; Br2 / 1.5 h / -20 °C 1.2: aq. NaNO2 / -20 - 15 °C 1.3: 85 percent / aq. NaOH / -10 - 20 °C 2.1: 67 percent / Pd(PPh3)4 / toluene / 48 h / Heating View Scheme
参考文献
Organic Letters, , vol. 2, # 21 p. 3373 - 3376
反应条件
1: 87 percent / NaNO2, Br2, 48percent HBr / 5 °C 2: 48 percent / KMnO4 / H2O / Heating 3: 1) NEt3, ethyl chloroformate, 2) LiAlH4 / 1) benzene, rt, 1 h, 2) THF, -78 deg C, 30 min View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 38, # 9 p. 2446 - 2458
反应条件
T=550°C; Further byproducts given;
参考文献
Journal of Chemical Research, Miniprint, , # 12 p. 4935 - 4953
