2-氨基-4-甲基吡啶合成路线 （共 193 条）
反应条件
1.1: nitric acid; sulfuric acid / 7.75 h / 20 - 50 °C 1.2: pH 9 2.1: copper(I) bromide; tert.-butylnitrite / acetonitrile / 2 h / 60 - 70 °C 3.1: N,N-dimethyl-formamide / 1 h / 100 °C 4.1: acetic acid; iron / 2 h / 20 - 70 °C View Scheme
参考文献
CENTAURUS BIOPHARMA CO., LTD.; XIAO, Dengming; ZHU, Yan; HU, Yuandong; WANG, Huting; LIU, Yuliang; LI, Jijun; SUN, Deguang; WANG, Zhe; WEI, Yongheng; WANG, Zanping; TANG, Guojing; JING, Lutao
Patent: WO2012/103806 A1, 2012 ;
WO 2012/103806 A1
反应条件
1.1: HBr; Br2 / H2O / 0.83 h / -20 °C 1.2: NaNO2 / H2O / 2.5 h / -20 °C 2.1: 72 percent / N-bromosuccinimide; benzoylperoxide / CCl4 / 4 h / Heating 3.1: 60 percent / CaCO3 / dimethylsulfoxide / 8 h / Heating View Scheme
参考文献
Ashimori; Ono; Uchida; Ohtaki; Fukaya; Watanabe; Yokoyama
Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 9 p. 2446 - 2458
反应条件
1: ethanol; bromine 2: concentrated H2SO4; concentrated HNO3 View Scheme
参考文献
BRISTOL-MYERS SQUIBB COMPANY; TRIPP, Jonathan Clive; FANFAIR, Dayne Dustan; SCHULTZ, Mitchell J.; MURUGESAN, Saravanababu; FOX, Richard J.; CHEN, Chung-Pin H.; IVY, Sabrina E.; PAYACK, Joseph Francis; DOUBLEDAY, Wendel W.
Patent: WO2012/106189 A1, 2012 ;
反应条件
1: NaHCO3 / tetrahydrofuran 2: KMnO4 / H2O / Heating 3: SOCl2 / methanol / Heating View Scheme
参考文献
Yoshida, Ken-Ichi; Nakayama, Kiyoshi; Kuru, Noriko; Kobayashi, Shozo; Ohtsuka, Masami; Takemura, Makoto; Hoshino, Kazuki; Kanda, Hiroko; Zhang, Jason Z.; Lee, Ving J.; Watkins, William J.
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 6 p. 1993 - 2004
参考文献
BRISTOL-MYERS SQUIBB COMPANY; TRIPP, Jonathan Clive; FANFAIR, Dayne Dustan; SCHULTZ, Mitchell J.; MURUGESAN, Saravanababu; FOX, Richard J.; CHEN, Chung-Pin H.; IVY, Sabrina E.; PAYACK, Joseph Francis; DOUBLEDAY, Wendel W.
Patent: WO2012/106189 A1, 2012 ;
Location in patent: Page/Page column 13 ;
参考文献
Buu-Hoi et al.
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1959 , vol. 248, p. 1832
反应条件
in xylene 1 h; Ambient temperature;
参考文献
Ocura, Haruo; Mineo, Satoshi; Nakagawa, Kunio
Chemical and Pharmaceutical Bulletin, 1981 , vol. 29, # 6 p. 1518 - 1524
反应条件
1: 64 percent / ethanol / 2 h / Heating 2: 36 percent / Ni-PO / benzene / 5 h / Heating View Scheme
参考文献
Ocura, Haruo; Mineo, Satoshi; Nakagawa, Kunio
Chemical and Pharmaceutical Bulletin, 1981 , vol. 29, # 6 p. 1518 - 1524
反应条件
1.1: nitric acid; sulfuric acid / 24 h / 0 - 50 °C 1.2: pH 7 / Cooling with ice 2.1: water; sodium nitrite; sulfuric acid / 0 °C / Reflux 3.1: trichlorophosphate / 4 h / Reflux 4.1: potassium dichromate; sulfuric acid / 8 h / 60 °C View Scheme
参考文献
Beijing Yiling Bioengineering Co., Ltd.
Patent: EP2366691 A1, 2011 ;
反应条件
sodium hydrogencarbonate
参考文献
Maury, G.; Pigiere, C.
Tetrahedron, 1981 , vol. 37, p. 83 - 90
