2-氨基-4-甲基吡啶合成路线 （共 193 条）
反应条件
1: With sulfuric acid T=0 - 5°C; 1 h; 2: With nitric acid in water T=-3 - 3°C; 2.25 h;
参考文献
Bhattacharya, Apurba; Purohit, Vikram C.; Deshpande, Prashant; Pullockaran, Annie; Grosso, John A.; DiMarco, John D.; Gougoutas, Jack Z.
Organic Process Research and Development, 2007 , vol. 11, # 5 p. 885 - 888
反应条件
in toluene 8 h; Heating;
参考文献
Georgescu, Florentina; Georgescu, Emilian; Draghici, Constantin; Iuhas, Paula C.; Filip, Petru I.
Revue Roumaine de Chimie, 2005 , vol. 50, # 5 p. 349 - 352
反应条件
in acetic acid 1.5 h; Heating;
参考文献
Kusar, Mihael; Svete, Jurij; Stanovnik, Branko
Journal of Heterocyclic Chemistry, 1996 , vol. 33, # 4 p. 1041 - 1046
反应条件
1: 2 h / |Reflux 2: diphenylether / 8 h / |Reflux View Scheme
参考文献
Mane; Li; Huang; Gupta; Nadkarni; Giridhar; Naik; Yadav
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 21 p. 6296 - 6304
反应条件
Montmorillonite K10; RhCl(PPh3)3 in toluene T=110°C; 2 h; Product distribution;
参考文献
Tetrahedron Letters, , vol. 44, # 8 p. 1631 - 1634
反应条件
1: 51 percent / NaNO2, HBF4 / 0 deg C to rt 2: 26 percent / KMnO4 / H2O / Heating 3: 1) NEt3, ethyl chloroformate, 2) LiAlH4 / 1) benzene, rt, 1 h, 2) THF, -78 deg C, 30 min View Scheme
参考文献
Ashimori; Ono; Uchida; Ohtaki; Fukaya; Watanabe; Yokoyama
Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 9 p. 2446 - 2458
反应条件
1: ethanol / 5 h / 20 °C 2: NaBH4 / tetrahydrofuran / 8 h / Heating 3: 48 percent / Br2 / acetic acid / 1 h / 20 °C View Scheme
参考文献
Lindstroem, Stefan; Ahmad, Tania; Grivas, Spiros
Heterocycles, 1994 , vol. 38, # 3 p. 529 - 540
反应条件
1: 4-methyl-pyridin-2-ylamine With hydrogenchloride in methanol T=10 - 30°C; 1.5 h; 2: nitrous acid methyl ester in methanol T=20 - 30°C; 13 h; 3: With sodium hydroxide in water T=30°C; pH=12;
参考文献
EP1679003 A1, ;
Page/Page column 20-21 ;
反应条件
hydrogen bromide; bromine; sodium nitrite und Erwaermen des Reaktionsprodukts mit Natriummethylat in tert-Butylalkohol;
参考文献
Adger, Brian M.; Ayrey, Peter; Bannister, Robin; Forth, Michael A.; Hajikarimian, Yousef; et al.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1988 , p. 2791 - 2796
参考文献
CYTOKINETICS, INC.
Patent: WO2006/47537 A1, 2006 ;
Location in patent: Page/Page column 33 ;
