2-氨基-4-甲基吡啶合成路线 （共 193 条）
反应条件
Acylation; 0.45 h; microwave irradiation;
参考文献
Suri; Satti
Synthetic Communications, 2000 , vol. 30, # 20 p. 3709 - 3718
反应条件
in xylene 2 h; Heating;
参考文献
Zupet; Tisler; Golic
Journal of Heterocyclic Chemistry, 1991 , vol. 28, # 7 p. 1731 - 1740
参考文献
Allen; Van Allan
Journal of Organic Chemistry, 1948 , vol. 13, p. 603,605
反应条件
1: 94 percent / 2-methyl-propan-2-ol 2: 1.) n-BuLi / 1) THF, hexane, rt, 30 min; 2) THF, hexane, -78 deg C, 15 min View Scheme
参考文献
Ihle; Krause
Journal of Organic Chemistry, 1996 , vol. 61, # 14 p. 4810 - 4811
反应条件
di-μ-chloro-bis(η4-1,5-cyclooctadiene)diiridium; Py2NP(i-Pr)2; potassium tert-butylate in tetrahydrofuran; diethylene glycol dimethyl ether T=110°C; 17 h;
参考文献
Blank, Benoit; Madalska, Martyna; Kempe, Rhett
Advanced Synthesis and Catalysis, 2008 , vol. 350, # 5 p. 749 - 758
反应条件
T=550°C; Further byproducts given;
参考文献
Busby, Reginald E.; Hussain, Syed M.; Mohamed, Murtedza bin; Parrick, John; Shaw, C. J. Granville; et al.
Journal of Chemical Research, Miniprint, 1980 , # 12 p. 4935 - 4953
反应条件
tert.-butylhydroperoxide; boron trifluoride diethyl etherate; tetra-(n-butyl)ammonium iodide in water; acetonitrile T=80°C; 10 h;
参考文献
Ma, Lijuan; Wang, Xianpei; Yu, Wei; Han, Bing
Chemical Communications, 2011 , vol. 47, # 40 p. 11333 - 11335
反应条件
aluminum oxide 0.0138889 h; Microwave irradiationneat (no solvent);
参考文献
Chunavala, Kaushik C.; Joshi, Girdhar; Suresh, Eringathodi; Adimurthy, Subbarayappa
Synthesis, 2011 , # 4 art. no. Z27510SS, p. 635 - 641
反应条件
1: concentrated H2SO4; concentrated HNO3 2: aqueous sulfuric acid; sodium nitrite / Diazotization 3: phosphorus (V)-chloride; phosphoryl chloride View Scheme
参考文献
TAKEDA PHARMACEUTICAL COMPANY LIMITED
Patent: WO2005/97129 A2, 2005 ;
WO 2005/097129 A2
反应条件
1: With sulfuric acid; nitric acid 2: With hydrogenchloride; sodium nitrite 3: With trichlorophosphate
参考文献
Timperley, Christopher M.; Banks, R. Eric; Young, Ian M.; Haszeldine, Robert N.
Journal of Fluorine Chemistry, 2011 , vol. 132, # 8 p. 541 - 547
