2-氨基-4-甲基吡啶合成路线 （共 193 条）
反应条件
anhydrous iron chloride in N,N-dimethyl-formamide
T=80°C; Michael Addition; 2 h;
参考文献
Santra, Sougata; Bagdi, Avik Kumar; Majee, Adinath; Hajra, Alakananda
Advanced Synthesis and Catalysis, 2013 , vol. 355, # 6 p. 1065 - 1070
反应条件
sodium carbonate in ethanol
Cyclization; Tschitschibabin reaction; 20 h; Heating;
参考文献
Tomoda, Haruhiko; Hirano, Takafumi; Saito, Shojiro; Mutai, Toshiki; Araki, Koji
Bulletin of the Chemical Society of Japan, 1999 , vol. 72, # 6 p. 1327 - 1334
反应条件
in ethanol
2.5 h; Ambient temperature;
参考文献
Parkanyi, Cyril; Abdelhamid, Abdou O.; Cheng, John C. S.
Journal of Heterocyclic Chemistry, 1984 , vol. 21, p. 1029 - 1032
反应条件
1: bromine
2: nitric acid; sulfuric acid
3: chloro-trimethyl-silane; sodium nitrite
5: sodium methylate; ammonium chloride / copper(l) iodide / tetrahydrofuran
View Scheme
参考文献
BRISTOL-MYERS SQUIBB COMPANY; TRIPP, Jonathan Clive; FANFAIR, Dayne Dustan; SCHULTZ, Mitchell J.; MURUGESAN, Saravanababu; FOX, Richard J.; CHEN, Chung-Pin H.; IVY, Sabrina E.; PAYACK, Joseph Francis; DOUBLEDAY, Wendel W.
Patent: WO2012/106189 A1, 2012 ;
参考文献
Ortho Pharmaceutical Corporation
Patent: US4727145 A1, 1988 ;
反应条件
sodium tris(acetoxy)borohydride; acetic acid in 1,2-dichloro-ethane
T=20°C; 24 h;
参考文献
Kawamura, Koji; Miyoshi, Keita; Kobayashi, Emi
Patent: US2012/142932 A1, 2012 ;
Location in patent: Page/Page column 5 ;
反应条件
triethylamine in tetrahydrofuran
1.) r.t., 2.) 60-70 deg C;
参考文献
Katsura; Nishino; Takasugi
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 11 p. 2937 - 2943
反应条件
1: 35.9 percent / Et3N / tetrahydrofuran / 1.) r.t., 2.) 60-70 deg C
2: 53.9 percent / hydrogen / 10 percent Pd-C / ethanol; tetrahydrofuran / 760 Torr / Ambient temperature
View Scheme
参考文献
Katsura; Nishino; Takasugi
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 11 p. 2937 - 2943
反应条件
in acetonitrile
Heating;
参考文献
Katsura; Nishino; Takasugi
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 11 p. 2937 - 2943
反应条件
acetic acid in benzene
4 h; Heating;
参考文献
Bruekelman, Stephen P.; Leach, (Miss) Susan E.; Meakins, G. Denis; Tirel, Malcolm D.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , p. 2801 - 2807
