2-氨基-4-甲基吡啶合成路线 （共 193 条）
反应条件
1.1: 75 percent / 4-dimethylaminopyridine / 5 h / Heating
2.1: 42 percent / potassium permanganate / H2O / 2.5 h / 50 - 90 °C
3.1: carbonyldiimidazole / dimethylformamide / 0.75 h / 20 °C
3.2: 65 percent / potassium tert-butoxide / dimethylformamide / 2 h / 120 °C
4.1: 55 percent / HBr / H2O / 30 h / Heating
View Scheme
参考文献
Wagner, Gerd K.; Kotschenreuther, Dunja; Zimmermann, Werner; Laufer, Stefan A.
Journal of Organic Chemistry, 2003 , vol. 68, # 11 p. 4527 - 4530
反应条件
air; copper–zinc supported on Al2O3–TiO2 in 1,2-dichloro-benzene
T=140°C; 20 h; Green chemistry;
参考文献
Meng, Xu; Yu, Chaoying; Zhao, Peiqing
RSC Advances, 2014 , vol. 4, # 17 p. 8612 - 8616
反应条件
1: 81 percent / pyridine
2: PCl5 / 1 h / 100 °C
3: sodium azide, sodium acetate / H2O; acetone / 12 h
4: 71 percent / 1,2,3,4-tetrahydro-naphthalene / 1 h / Heating
View Scheme
参考文献
Rao, P. Jayaprasad; Reddy, K. Kondal
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1983 , vol. 22, p. 117 - 120
反应条件
1.1: 85 percent / Br2; aq. HBr; NaNO2 / 0 °C
2.1: n-BuLi / tetrahydrofuran / 0.33 h / -78 °C
2.2: selenium / tetrahydrofuran / -78 - 20 °C
2.3: 60 percent / air / tetrahydrofuran / 0.5 h / 20 °C
View Scheme
参考文献
Bhasin; Venugopalan; Singh
Phosphorus, Sulfur and Silicon and the Related Elements, 2002 , vol. 177, # 11 p. 2579 - 2587
反应条件
1.1: propan-2-ol / Heating
1.2: 76 percent / hydroxylamine hydrochloride / propan-2-ol / 50 °C
2.1: 68 percent / trifluoroacetic anhydride / tetrahydrofuran / 20 °C
View Scheme
参考文献
Huntsman, Elliott; Balsells, Jaume
European Journal of Organic Chemistry, 2005 , # 17 p. 3761 - 3765
反应条件
1: NaNO2; HBr; Br2
2: KMnO4
3: K2CO3 / 160 °C
4: H2SO4 / Heating
View Scheme
参考文献
Al-Jammaz, I.; Al Otaibi, B.; Amartey, J. K.
Journal of Labelled Compounds and Radiopharmaceuticals, 2001 , vol. 44, p. S451 - S454
反应条件
1: sulfuric acid; dihydrogen peroxide / 0 - 20 °C
2: UHP; trifluoroacetic anhydride / dichloromethane / 0 - 20 °C
3: tetrahydrofuran / -50 °C / |Inert atmosphere
View Scheme
参考文献
Zhang, Fang; Zhang, Song; Duan, Xin-Fang
Organic Letters, 2012 , vol. 14, # 21 p. 5618 - 5620
参考文献
Boehringer Ingelheim GmbH
Patent: US3992535 A1, 1976 ;
参考文献
Boehringer Ingelheim GmbH
Patent: US3992535 A1, 1976 ;
反应条件
1: in N,N-dimethyl-formamide
T=85°C; 6 h;
2: With copper(l) iodide; caesium carbonate; L-proline in N,N-dimethyl-formamide
T=80 - 85°C; 6 h;
参考文献
Maity, Arindam; Mondal, Shyamal; Paira, Rupankar; Hazra, Abhijit; Naskar, Subhendu; Sahu, Krishnendu B.; Saha, Pritam; Banerjee, Sukdeb; Mondal, Nirup B.
Tetrahedron Letters, 2011 , vol. 52, # 23 p. 3033 - 3037
