2-氨基-4-甲基吡啶合成路线 （共 193 条）
反应条件
sodium nitrite in hydrogenchloride
参考文献
SmithKline Beecham Corporation
Patent: US2002/91264 A1, 2002 ;
反应条件
1: 4-methyl-pyridin-2-ylamine With hydrogenchloride in methanol T=10 - 30°C; 1.5 h; 2: nitrous acid methyl ester in methanol T=20 - 30°C; 13 h; 3: With sodium hydroxide in water T=30°C; pH=12;
参考文献
ISHIHARA SANGYO KAISHA, LTD.
Patent: EP1679003 A1, 2006 ;
Location in patent: Page/Page column 20-21 ;
反应条件
1: potassium permanganate View Scheme
参考文献
Wagner, Gerd K.; Kotschenreuther, Dunja; Zimmermann, Werner; Laufer, Stefan A.
Journal of Organic Chemistry, 2003 , vol. 68, # 11 p. 4527 - 4530
反应条件
hydrogen bromide; bromine; sodium nitrite in water T=0°C; 3 h;
参考文献
Bonnet, Veronique; Mongin, Florence; Trecourt, Francois; Queguiner, Guy; Knochel, Paul
Tetrahedron, 2002 , vol. 58, # 22 p. 4429 - 4438
参考文献
Merck and Co., Inc.
Patent: US6127390 A1, 2000 ;
US 6127390 A
反应条件
1: I2; H5IO6; H2SO4 / H2O; acetic acid / 80 °C 2: 78 percent / NaNO2; HCl / 20 °C View Scheme
参考文献
ZOETIS LLC; MENON, Sanjay; SHEEHAN, Susan M.K.; VAILLIANCOURT, Valerie A.
Patent: WO2014/39484 A1, 2014 ;
反应条件
1: sodium nitrite; aqueous tetrafluoroboric acid / Diazotization 2: KMnO4; H2O View Scheme
参考文献
Roe et al.
Journal of the American Chemical Society, 1949 , vol. 71, p. 4152
反应条件
1: 84 percent / AcOH / benzene / 4 h / Heating 2: 90 percent / n-BuLi, i-Pr2NH / hexane; tetrahydrofuran / 1.) -25 deg C, 70 min, 2.) 2 h 3: 90 percent / H2NOH*HCl / ethanol; H2O / 24 h / Heating View Scheme
参考文献
Bruekelman, Stephen P.; Leach, (Miss) Susan E.; Meakins, G. Denis; Tirel, Malcolm D.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , p. 2801 - 2807
反应条件
1: 2 h / |Reflux 2: diphenylether / 8 h / |Reflux 3: hydrogenchloride / 2 h / |Reflux View Scheme
参考文献
Mane; Li; Huang; Gupta; Nadkarni; Giridhar; Naik; Yadav
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 21 p. 6296 - 6304
反应条件
bromine in sulfuric acid
参考文献
SmithKline Beecham Corporation
Patent: US6440993 B1, 2002 ;
US 6440993 B1
