2-氨基-4-甲基吡啶合成路线 （共 193 条）
反应条件
N-chloro-succinimide in N,N-dimethyl-formamide T=50°C; 3 h;
参考文献
ERRICO, Joseph P.; MUGRAGE, Benjamin; TURCHI, Ignatius; SILLS, Matthew; ONG, Jane; ALLOCCO, John; WINES, Pam
Patent: WO2011/85126 A2, 2011 ;
Location in patent: Page/Page column 166 ;
WO 2011/085126 A1
反应条件
1: 94 percent / HBr; Br2; NaNO2 / H2O / 3 h / 0 °C 2: 31 percent / KMnO4 / H2O / 5 h / Heating 3: 55 percent / conc. H2SO4 / 3 h / Heating View Scheme
参考文献
Bonnet, Veronique; Mongin, Florence; Trecourt, Francois; Queguiner, Guy; Knochel, Paul
Tetrahedron, 2002 , vol. 58, # 22 p. 4429 - 4438
反应条件
tert.-butylhydroperoxide; 3 A molecular sieve; zirconium tetra-t-butoxide in dichloromethane 24 h; Ambient temperature;
参考文献
Krohn, Karsten; Kuepke, Jochen; Rieger, Hagen
Advanced Synthesis and Catalysis, 1997 , vol. 339, # 4 p. 335 - 339
参考文献
Wiley; Hartman
Journal of the American Chemical Society, 1951 , vol. 73, p. 494
反应条件
1.1: 70 percent / bromine; acetic acid / 3 h / 50 °C 2.1: sodium nitrite; concd. hydrochloric acid / 1 h / -20 °C 2.2: 48 percent / aq. sodium hydroxide / 0 - 5 °C / pH 11 View Scheme
参考文献
Cheng, Jie; Xu, Liang; Stevens, Edwin D.; Trudell, Mark L.; Izenwasser, Sari; Wade, Dean
Journal of Heterocyclic Chemistry, 2004 , vol. 41, # 4 p. 569 - 574
反应条件
1: toluene-4-sulfonic acid / tetrahydrofuran / 18 h / Molecular sieve; Inert atmosphere; Reflux 2: tetrahydrofuran / -78 - 20 °C / Molecular sieve; Inert atmosphere 3: [copperl(II)(1,1,1,5,5,5-hexafluoroacetylacetonate)2] monohydrate; oxygen / N,N-dimethyl-formamide / 10 h / 105 °C View Scheme
参考文献
Wang, Honggen; Wang, Yong; Liang, Dongdong; Liu, Lanying; Zhang, Jiancun; Zhu, Qiang
Angewandte Chemie - International Edition, 2011 , vol. 50, # 25 p. 5678 - 5681
反应条件
sulfuric acid; nitric acid T=0 - 70°C; 4 h;
参考文献
Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, , vol. 96, p. 952 - 962
反应条件
1: With sulfuric acid; nitric acid T=0 - 50°C; 24 h; 2: in water pH=7; Cooling with ice;
参考文献
EP2366691 A1, ;
Page/Page column 6-7 ;
反应条件
1: bromine; aqueous sodium nitrite solution; aqueous hydrobromic acid 2: copper / 240 °C 3: KMnO4; H2O View Scheme
参考文献
Case
Journal of the American Chemical Society, 1946 , vol. 68, p. 2574,2576
反应条件
1: 94 percent / HBr; Br2; NaNO2 / H2O / 3 h / 0 °C 2: 31 percent / KMnO4 / H2O / 5 h / Heating View Scheme
参考文献
Tetrahedron, , vol. 58, # 22 p. 4429 - 4438
