2-氨基-4-甲基吡啶合成路线 （共 193 条）
反应条件
1: With acetic acid Reflux; 2: With ammonium hydroxide pH=9;
参考文献
ASCEPION PHARMACEUTICALS, INC.; JIANG, Shan; GAO, Xiaoyong; WANG, Qishan
Patent: WO2012/28106 A1, 2012 ;
Location in patent: Page/Page column 45 ;
WO 2012/028106 A1
反应条件
sodium hydroxide; ethyl orthosilicate T=140°C; 24 h;
参考文献
Zhang, Wen; Leng, Xuebing; Sun, Wen-Hua
Journal of Chemical Research - Part S, 2003 , # 12 p. 808 - 809
反应条件
1.1: sulfuric acid; sodium nitrite / water / 2.25 h / 0 - 95 °C 1.2: 20 °C / pH 6 - 7 2.1: N-bromosuccinmide; acetic acid / ethyl acetate / 0.5 h / 20 °C 2.2: pH 8 3.1: silver carbonate / dichloromethane / 144 h / |Inert atmosphere View Scheme
参考文献
AB SCIENCE; BENJAHAD, Abdellah; MOUSSY, Alain; CHEVENIER, Emmanuel; PICOUL, Willy; LERMET, Anne; PEZ, Didier; MARTIN, Jason; SANDRINELLI, Franck
Patent: WO2013/14170 A1, 2013 ;
WO 2013/014170 A1
反应条件
1: concentrated H2SO4; concentrated HNO3 2: aqueous sulfuric acid; sodium nitrite / Diazotization 3: phosphorus (V)-chloride; phosphoryl chloride 4: methanol View Scheme
参考文献
Besly; Goldberg
Journal of the Chemical Society, 1954 , p. 2448,2455
反应条件
1: bromine; aqueous sodium nitrite solution; aqueous hydrobromic acid 2: copper / 240 °C 3: KMnO4; H2O 4: H2SO4 View Scheme
参考文献
Case
Journal of the American Chemical Society, 1946 , vol. 68, p. 2574,2576
反应条件
1: NaNO2; HBr; Br2 2: KMnO4 3: K2CO3 / 160 °C View Scheme
参考文献
Al-Jammaz, I.; Al Otaibi, B.; Amartey, J. K.
Journal of Labelled Compounds and Radiopharmaceuticals, 2001 , vol. 44, p. S451 - S454
反应条件
1,10-phenanthroline; copper (II) acetate monohydrate; zinc(II) iodide in 1,2-dichloro-benzene T=120°C; 24 h;
参考文献
Bagdi, Avik Kumar; Rahman, Matiur; Santra, Sougata; Majee, Adinath; Hajra, Alakananda
Advanced Synthesis and Catalysis, 2013 , vol. 355, # 9 p. 1741 - 1747
反应条件
in ethanol 5 h; Heating;
参考文献
Saddik; Khoutoul; Benchat; Hammouti; S. El Kadiri; Touzani
Research on Chemical Intermediates, 2012 , vol. 38, # 9 p. 2457 - 2470
参考文献
Shapiro et al.
Journal of Organic Chemistry, 1959 , vol. 24, p. 1606
参考文献
Katritzky
Journal of the Chemical Society, 1956 , p. 2063,2065
