2,4,6-三甲基苯乙醇合成路线 （共 17 条）
反应条件
1: LiAlH4; diethyl ether
2: hydrogen; CO; benzene / 190 °C / Reagens 4: Octacarbonyldikobalt; Reagens 5: CoCO3
View Scheme
参考文献
Wender et al.
Journal of the American Chemical Society, 1952 , vol. 74, p. 4079,4082
反应条件
lithium aluminium tetrahydride
参考文献
Bost et al.
Journal of Organic Chemistry, 1957 , vol. 22, p. 51,54
反应条件
sodium hydroxide; bis(1,5-cyclooctadiene)-rhodium(I) tetrafluoroborate; dihydrogen peroxide; 1,4-di(diphenylphosphino)-butane; benzo[1,3,2]dioxaborole
1.) THF, 25 deg C, 16 h, 2.) THF, RT, 3 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Hayashi; Matsumoto; Ito
Tetrahedron Asymmetry, 1991 , vol. 2, # 7 p. 601 - 612
反应条件
1: 82 percent / pyridine; DMAP
2: 54 percent / I2; PhI(OOCCF3)2
3: 47 percent / Et3N / Pd(PPh3)2Cl2
4: 96 percent / KF; 18-crown-6
5: 72 percent / TfOH / Au(PPh3)CH3 / methanol; H2O
6: 17 percent / N-methylimidazole / 2-methyl-propan-2-ol / Irradiation
View Scheme
参考文献
Wessig, Pablo; Teubner, Janek
Synlett, 2006 , # 10 p. 1543 - 1546
反应条件
phosphorus tribromide
参考文献
Sordes
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1932 , vol. 195, p. 247
反应条件
sulfur trioxide pyridine complex; dimethyl sulfoxide; triethylamine
Swern oxidation;
参考文献
Aso, Kazuyoshi; Kobayashi, Katsumi; Mochizuki, Michiyo; Kanzaki, Naoyuki; Sako, Yuu; Yano, Takahiko
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 8 p. 2365 - 2371
反应条件
1: 82 percent / pyridine; DMAP
2: 54 percent / I2; PhI(OOCCF3)2
3: 47 percent / Et3N / Pd(PPh3)2Cl2
4: 96 percent / KF; 18-crown-6
5: 72 percent / TfOH / Au(PPh3)CH3 / methanol; H2O
6: 17 percent / N-methylimidazole / 2-methyl-propan-2-ol / Irradiation
7: 91 percent / K2CO3 / methanol
8: 43 percent / LDA
View Scheme
参考文献
Wessig, Pablo; Teubner, Janek
Synlett, 2006 , # 10 p. 1543 - 1546
