(2R)-2-氨基-2-(4-甲基苯基)乙酸合成路线 (共 3 条)
反应条件
sodium dihydrogenphosphate; superheavy water T=80.2 - 110.3°C; pH 10.0; Ea, ΔH(excit.), ΔS(excit.); Thermodynamic data;
参考文献
Smith, Grant Gill; Sivakua, Thipamon
Journal of Organic Chemistry, 1983 , vol. 48, # 5 p. 627 - 634
反应条件
1.1: ammonium chloride
1.2: 24 h / 20 °C
2.1: hydrogenchloride / water / 3 h / 20 °C
3.1: PLP / aq. buffer / 36 h / 40 °C / pH 8.0 / |Enzymatic reaction
View Scheme
参考文献
Yasukawa, Kazuyuki; Asano, Yasuhisa
Advanced Synthesis and Catalysis, 2012 , vol. 354, # 17 p. 3327 - 3332
反应条件
potassium hydroxide; ammonia; (+)-(1S,2R)-N-hexadecyl-N-methylephedrinium bromide; lithium chloride in ethanol
5 deg C, 4 h, RT, overnight; asymmetric induction; Product distribution;
参考文献
Zhang, Yongmin; Li, Weixing
Synthetic Communications, 1988 , vol. 18, # 14 p. 1685 - 1690