(4-溴苯基)环丙基甲酮合成路线 （共 10 条）
反应条件
AlCl3, aluminium chloride in neat (no solvent) T=20°C; Friedel-Crafts Acylation; Inert atmosphere;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 23, # 24 p. 6629 - 6635
反应条件
potassium hydroxide in methanol cooling to 20 deg C;
参考文献
Schliemann; Buege; Reppel
Pharmazie, 1980 , vol. 35, # 3 p. 140 - 143
反应条件
1: 25 percent / AlCl3 / 1 h / 20 °C 2: 44.1 percent / KOH / methanol / cooling to 20 deg C View Scheme
参考文献
Pharmazie, , vol. 35, # 3 p. 140 - 143
参考文献
Chemische Berichte, , vol. 96, p. 2532 - 2536
反应条件
hydrogenchloride; sodium hydroxide; iron(III) chloride; CuCN in water; N,N-dimethyl-formamide
参考文献
Hoechst Aktiengesellschaft
Patent: US5981492 A1, 1999 ;
反应条件
in N,N-dimethyl-formamide 4 h; Heating;
参考文献
Stilz; Guba; Jablonka; Just; Klingler; Koenig; Wehner; Zoller
Journal of Medicinal Chemistry, 2001 , vol. 44, # 8 p. 1158 - 1176
反应条件
lithium aluminium tetrahydride
参考文献
Hanack,M. et al.
Chemische Berichte, 1963 , vol. 96, p. 2532 - 2536
反应条件
ZnF2; tris-(dibenzylideneacetone)dipalladium(0); tri-tert-butyl phosphine in DMF (N,N-dimethyl-formamide)
T=80°C; 18 h;
参考文献
AMR Technology, Inc.
Patent: US2006/63808 A1, 2006 ;
Location in patent: Page/Page column 11; 14 ;
反应条件
copper(I) oxide; ammonium hydroxide in dimethyl sulfoxide
T=90°C; 16 h; Sealed tube;
参考文献
Rennison, David; Conole, Daniel; Tingle, Malcolm D.; Yang, Junpeng; Eason, Charles T.; Brimble, Margaret A.
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 24 p. 6629 - 6635
反应条件
1: in tetrahydrofuran; diethyl ether
T=-78 - 20°C; 2.16667 h;
2: With ammonium chloride in tetrahydrofuran; diethyl ether; water
T=20°C; Product distribution / selectivity;
参考文献
Boehringer Ingelheim International GmbH; BYLOCK, Lars Anders
Patent: US2013/195879 A1, 2013 ;
Location in patent: Paragraph 0224 ;
