1-戊基-N-苄基-1H-吲哚-3-甲酰胺合成路线 （共 6 条）
反应条件
triethylamine in dichloromethane
14 h; Inert atmosphere;
参考文献
Banister, Samuel D.; Wilkinson, Shane M.; Longworth, Mitchell; Stuart, Jordyn; Apetz, Nadine; English, Katrina; Brooker, Lance; Goebel, Catrin; Hibbs, David E.; Glass, Michelle; Connor, Mark; McGregor, Iain S.; Kassiou, Michael
ACS Chemical Neuroscience, 2013 , vol. 4, # 7 p. 1081 - 1092
反应条件
1.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0.17 h / 20 °C / |Inert atmosphere
1.2: 0 - 20 °C / |Inert atmosphere
2.1: mineral oil; N,N-dimethyl-formamide / 1 h / 0 - 20 °C / |Inert atmosphere
3.1: potassium hydroxide / toluene; methanol / 2 h / |Inert atmosphere; |Reflux
4.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1 h / |Inert atmosphere
5.1: triethylamine / dichloromethane / 14 h / |Inert atmosphere
View Scheme
参考文献
Banister, Samuel D.; Wilkinson, Shane M.; Longworth, Mitchell; Stuart, Jordyn; Apetz, Nadine; English, Katrina; Brooker, Lance; Goebel, Catrin; Hibbs, David E.; Glass, Michelle; Connor, Mark; McGregor, Iain S.; Kassiou, Michael
ACS Chemical Neuroscience, 2013 , vol. 4, # 7 p. 1081 - 1092
反应条件
1: mineral oil; N,N-dimethyl-formamide / 1 h / 0 - 20 °C / |Inert atmosphere
2: potassium hydroxide / toluene; methanol / 2 h / |Inert atmosphere; |Reflux
3: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1 h / |Inert atmosphere
4: triethylamine / dichloromethane / 14 h / |Inert atmosphere
View Scheme
参考文献
Banister, Samuel D.; Wilkinson, Shane M.; Longworth, Mitchell; Stuart, Jordyn; Apetz, Nadine; English, Katrina; Brooker, Lance; Goebel, Catrin; Hibbs, David E.; Glass, Michelle; Connor, Mark; McGregor, Iain S.; Kassiou, Michael
ACS Chemical Neuroscience, 2013 , vol. 4, # 7 p. 1081 - 1092
反应条件
1.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0.17 h / 20 °C / |Inert atmosphere
1.2: 0 - 20 °C / |Inert atmosphere
2.1: mineral oil; N,N-dimethyl-formamide / 1 h / 0 - 20 °C / |Inert atmosphere
3.1: potassium hydroxide / toluene; methanol / 2 h / |Inert atmosphere; |Reflux
4.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1 h / |Inert atmosphere
5.1: triethylamine / dichloromethane / 14 h / |Inert atmosphere
View Scheme
参考文献
Banister, Samuel D.; Wilkinson, Shane M.; Longworth, Mitchell; Stuart, Jordyn; Apetz, Nadine; English, Katrina; Brooker, Lance; Goebel, Catrin; Hibbs, David E.; Glass, Michelle; Connor, Mark; McGregor, Iain S.; Kassiou, Michael
ACS Chemical Neuroscience, 2013 , vol. 4, # 7 p. 1081 - 1092
反应条件
1: potassium hydroxide / toluene; methanol / 2 h / |Inert atmosphere; |Reflux
2: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1 h / |Inert atmosphere
3: triethylamine / dichloromethane / 14 h / |Inert atmosphere
View Scheme
参考文献
Banister, Samuel D.; Wilkinson, Shane M.; Longworth, Mitchell; Stuart, Jordyn; Apetz, Nadine; English, Katrina; Brooker, Lance; Goebel, Catrin; Hibbs, David E.; Glass, Michelle; Connor, Mark; McGregor, Iain S.; Kassiou, Michael
ACS Chemical Neuroscience, 2013 , vol. 4, # 7 p. 1081 - 1092
反应条件
1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1 h / |Inert atmosphere
2: triethylamine / dichloromethane / 14 h / |Inert atmosphere
View Scheme
参考文献
Banister, Samuel D.; Wilkinson, Shane M.; Longworth, Mitchell; Stuart, Jordyn; Apetz, Nadine; English, Katrina; Brooker, Lance; Goebel, Catrin; Hibbs, David E.; Glass, Michelle; Connor, Mark; McGregor, Iain S.; Kassiou, Michael
ACS Chemical Neuroscience, 2013 , vol. 4, # 7 p. 1081 - 1092
