5-苄氧基吲哚-3-甲醛合成路线 （共 13 条）
反应条件
1: N,N-dimethyl-formamide With trichlorophosphate T=0°C; 0.25 h; 2: 5-phenylmethoxy-1H-indole T=50 - 60°C; 1.5 h; 3: With sodium hydroxide in water T=0°C; 0.0333333 h; Heating / reflux;
参考文献
ASTRAZENECA AB
Patent: WO2005/66132 A1, 2005 ;
Location in patent: Page/Page column 90-91 ;
WO 2005/066132 A1
反应条件
1: With acetic anhydride T=130°C; 1 h; 2: With sodium hydroxide in ethanol; water 1 h; Heating; Further stages.;
参考文献
Aoki, Katsuyuki; Koseki, Jyun-Ichi; Takeda, Shuichi; Aburada, Masaki; Miyamoto, Ken-Ichi
Chemical and Pharmaceutical Bulletin, 2007 , vol. 55, # 6 p. 922 - 925
反应条件
1: potassium carbonate / acetone / 5 h / Heating 2: 2.) hydrazine hydrate / 2.) Raney nickel / 1.) reflux, 3 h, 2.) THF, MeOH, RT, 30 min 3: 1.) phosphorus oxychloride, 2.) conc. HCl / 1.) 0 deg C, 1 h, 2.) MeOH, THF, RT, 45 min View Scheme
参考文献
Journal of medicinal chemistry, , vol. 38, # 13 p. 2331 - 2338
反应条件
1: potassium carbonate / acetone / 5 h / Heating 2: 2.) hydrazine hydrate / 2.) Raney nickel / 1.) reflux, 3 h, 2.) THF, MeOH, RT, 30 min 3: 1.) phosphorus oxychloride, 2.) conc. HCl / 1.) 0 deg C, 1 h, 2.) MeOH, THF, RT, 45 min View Scheme
参考文献
Journal of medicinal chemistry, , vol. 38, # 13 p. 2331 - 2338
反应条件
1: 2.) hydrazine hydrate / 2.) Raney nickel / 1.) reflux, 3 h, 2.) THF, MeOH, RT, 30 min 2: 1.) phosphorus oxychloride, 2.) conc. HCl / 1.) 0 deg C, 1 h, 2.) MeOH, THF, RT, 45 min View Scheme
参考文献
Journal of medicinal chemistry, , vol. 38, # 13 p. 2331 - 2338
反应条件
1: copper oxide-chromium oxide; quinoline / 280 °C 2: phosphoryl chloride / und anschliessenden Hydrolysieren mit wss.Natronlauge bzw. wss.Natriumcarbonat-Loesung View Scheme
参考文献
Journal of the Chemical Society, , p. 3887,3892
反应条件
und Erwaermen des Reaktionsprodukts mit wss.Natronlauge oder mit wss.Natriumcarbonat-Loesung.;
参考文献
Journal of the Chemical Society, , p. 3493,3494
Journal of the Chemical Society, , p. 3887,3892
反应条件
1: ammonium acetate 2: LiAlH4; diethyl ether 3: methanol; palladium/charcoal / Hydrogenation View Scheme
参考文献
Ash; Wragg
Journal of the Chemical Society, 1958 , p. 3887,3892
反应条件
1,3-dimethyl-imidazolidin-2-one; sodium hexamethyldisilazane in tetrahydrofuran T=185°C; 12 h;
参考文献
Jih, Ru Hwu; Fung, Fuh Wong
European Journal of Organic Chemistry, 2006 , # 11 p. 2513 - 2516
