2,2-二甲基-[1,1-联苯]-4-羧酸合成路线 （共 2 条）
反应条件
1: With methanol; sodium hydroxide; water in tetrahydrofuran
1 h; Heating / reflux;
2: With hydrogenchloride in tetrahydrofuran
T=0°C; 1 h;
参考文献
WYETH
Patent: US2006/287522 A1, 2006 ;
Location in patent: Page/Page column 25 ;
US 20060287522 A1
反应条件
disodium hydrogenphosphate; Pd(OAc)2(2-amino-4,6-dihydroxypyrimidine disodium salt)2 in water
T=120°C; Suzuki-Miyaura coupling; 0.166667 h; Microwave irradiation;
参考文献
Chalker, Justin M.; Wood, Charlotte S. C.; Davis, Benjamin G.
Journal of the American Chemical Society, 2009 , vol. 131, # 45 p. 16346 - 16347
