4,4’-二氰基二苯溴甲烷合成路线 （共 7 条）
反应条件
hydrogen bromide in water; toluene T=60°C; 2 h; Heating / reflux;
参考文献
CHEMAGIS LTD.
Patent: US2007/112202 A1, 2007 ;
Location in patent: Page/Page column 7 ;
反应条件
N-bromosuccinmide in tetrachloromethane 1 h; RefluxInert atmosphere;
参考文献
Doiron, Jeremie; Soultan, Al Haliffa; Richard, Ryan; Toure, Mamadou Mansour; Picot, Nadia; Richard, Remi; Cuperlovic-Culf, Miroslava; Robichaud, Gilles A.; Touaibia, Mohamed
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 9 p. 4010 - 4024
反应条件
1.1: potassium tert-butylate / N,N-dimethyl-formamide / 1 h / -5 °C / Inert atmosphere 1.2: 1 h / -5 °C / Inert atmosphere 2.1: N-bromosuccinmide / tetrachloromethane / 1 h / Reflux; Inert atmosphere View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 46, # 9 p. 4010 - 4024
反应条件
1.1: potassium tert-butylate / N,N-dimethyl-formamide / 1 h / -5 °C / Inert atmosphere 1.2: 1 h / -5 °C / Inert atmosphere 2.1: N-bromosuccinmide / tetrachloromethane / 1 h / Reflux; Inert atmosphere View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 46, # 9 p. 4010 - 4024
反应条件
potassium carbonate in N,N-dimethyl-formamide; toluene T=60 - 80°C; 1.5 h; Product distribution / selectivity;
参考文献
US2007/112202 A1, ;
Page/Page column 7 ;
反应条件
potassium carbonate in N,N-dimethyl-formamide; toluene T=60 - 80°C; 1.5 h; Product distribution / selectivity;
参考文献
US2007/112202 A1, ;
Page/Page column 7 ;
反应条件
tetrabutylammomium bromide; potassium carbonate in isopropyl alcohol 8 - 9 h; Heating / reflux; Product distribution / selectivity;
参考文献
NATCO PHARMA LIMITED; KOMPELLA, Amala, kishan; RACHAKONDA, Srinivas; ADIBHATLA KALI SATYA, Bhujanga, Rao; VENKAIAH CHOWDARY, Nannapaneni
Patent: WO2007/144896 A1, 2007 ;
Location in patent: Page/Page column 7; 10 ;
