1: HOBT-dicyclohexylcarbodiimide 2: TFA-anisole 3: HOBT, dicyclohexylcarbodiimide 4: HF, anisole-thioanisole-o-cresol / 0.5 h / ice bath View Scheme

1: TFA-anisole 2: HOBT-dicyclohexylcarbodiimide 3: TFA-anisole 4: HOBT, dicyclohexylcarbodiimide 5: HF, anisole-thioanisole-o-cresol / 0.5 h / ice bath View Scheme

1: HOBT, dicyclohexylcarbodiimide 2: HF, anisole-thioanisole-o-cresol / 0.5 h / ice bath View Scheme

1: TFA-anisole 2: HOBT, dicyclohexylcarbodiimide 3: HF, anisole-thioanisole-o-cresol / 0.5 h / ice bath View Scheme

1: fmoc-O-tert-butyl-L-tyrosine With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; diisopropyl-carbodiimide in N,N-dimethyl-formamide 1 h; 2: With piperidine in N,N-dimethyl-formamide 0.5 h; 3: N-(fluoren-9-ylmethoxycarbonyl)-L-Val; N-(9-fluorenylmethoxycarbonyl)-L-aspartic acid-β-(tert-butyl)ester; N-(fluoren-9-ylmethoxycarbonyl)-L-Lys(Nε-Boc); N-α-Fmoc-N-ω,N-ω'-bis-tert-butoxycarbonyl-L-arginine Further stages;

Multistep reaction;