1: piperonal; diisopropyl (2-((3,4-dimethoxyphenethyl)amino)-2-oxoethyl)phosphonate With potassium tert-butylate in tetrahydrofuran T=20°C; Horner-Wadsworth-Emmons Olefination; 6 h; 2: (carboxymethyl)trimethylammonium chloride hydrazide in tetrahydrofuran; methanol stereoselective reaction;