4-(2-氟苯基)-1-甲基哌啶-4-甲腈合成路线 （共 5 条）
反应条件
lithium aluminium tetrahydride; LiAlH(OEt)3 in ethylene glycol dimethyl ether 72 h; Heating;
参考文献
Ong; Profitt; Fortunato; Glamkowski; Ellis; Geyer; Wilker; Burghard
Journal of Medicinal Chemistry, 1983 , vol. 26, # 7 p. 981 - 986
反应条件
lithium aluminium tetrahydride in ethylene glycol dimethyl ether 64 h; Heating;
参考文献
Journal of Medicinal Chemistry, , vol. 26, # 7 p. 981 - 986
反应条件
1: dimethylsulfoxide / 2 h / Ambient temperature
2: 1.) sodium hydride / 1.) DMF, r.t., 30 min; 2.) DMF, 90 degC, 16h
View Scheme
参考文献
Ong, Helen H.; Agnew, Marc N.
Journal of Heterocyclic Chemistry, 1981 , vol. 18, p. 815 - 820
反应条件
sodium hydride
1.) DMSO, 30 min, 2.) DMSO, 75 deg C, 4 h; Yield given. Multistep reaction;
参考文献
Ong; Profitt; Fortunato; Glamkowski; Ellis; Geyer; Wilker; Burghard
Journal of Medicinal Chemistry, 1983 , vol. 26, # 7 p. 981 - 986
反应条件
sodium hydride
1.) DMF, r.t., 30 min; 2.) DMF, 90 degC, 16h; Yield given. Multistep reaction;
参考文献
Ong, Helen H.; Agnew, Marc N.
Journal of Heterocyclic Chemistry, 1981 , vol. 18, p. 815 - 820
