1: sulfuric acid; aqueous nitric acid 2: SnCl2; aqueous HCl View Scheme

potassium fluoride; {palladium-dichloro-(P(C3H7)3)2} in N,N-dimethyl-formamide T=150°C; 20 h;

aluminium trichloride Acylation;

aluminium trichloride

1: 80 percent / AlCl3 2: 90 percent / 5 percent NaOCl View Scheme

1.1: palladium diacetate; potassium iodide; 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl; triethylamine / ethyl acetate / 16 h / 50 °C / |Inert atmosphere; |Schlenk technique 2.1: methanol / ethyl acetate / 1 h / -5 - 20 °C / |Inert atmosphere; |Schlenk technique 2.2: 4 h / 20 °C / |Inert atmosphere; |Schlenk technique View Scheme

nitric acid T=0 - 20°C;

1: PTAS With tetrabutyl ammonium fluoride in tetrahydrofuran; water T=20°C; 1 h; 2: 1-Chloro-3,4-difluoro-benzene With 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl; bis(η3-allyl-μ-chloropalladium(II)) in tetrahydrofuran; water T=80°C; 3 h;

bromine; iron T=20 - 72°C;