2-甲基-4(5)硝基咪唑合成路线 （共 56 条）
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=0 - 20°C;
参考文献
Lu, Guo-Liang; Ashoorzadeh, Amir; Anderson, Robert F.; Patterson, Adam V.; Smaill, Jeff B.
Tetrahedron, 2013 , vol. 69, # 43 p. 9130 - 9138
反应条件
18-crown-6 ether; potassium carbonate in N,N-dimethyl-formamide
T=100°C; 10 h;
参考文献
Lissel, Manfred
Liebigs Annalen der Chemie, 1987 , p. 77 - 80
参考文献
Bhagwat; Pyman
Journal of the Chemical Society, 1925 , vol. 127, p. 1835
反应条件
sodium hydrogencarbonate in water
Heating;
参考文献
Rao, A. K. S. Bhujanga; Prasad, Ramanujam S.; Rao, C. Gundu; Singh, Bajrang B.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1989 , p. 1352 - 1353
反应条件
tetra-(n-butyl)ammonium iodide; potassium carbonate in acetonitrile
T=75°C; 2 h;
参考文献
Kim, Pilho; Zhang, Liang; Manjunatha, Ujjini H.; Singh, Ramandeep; Patel, Sejal; Jiricek, Jan; Keller, Thomas H.; Boshoff, Helena I.; Barry III, Clifton E.; Dowd, Cynthia S.
Journal of Medicinal Chemistry, 2009 , vol. 52, # 5 p. 1317 - 1328
反应条件
tetrabutylammomium bromide; potassium carbonate
T=70 - 80°C; 2 h;
参考文献
Liu; Chen; Cao; Li
Synthetic Communications, 1993 , vol. 23, # 18 p. 2611 - 2615
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=110 - 120°C; 3 h;
参考文献
Bhujanga Rao; Gundu Rao; Sing
Synthetic Communications, 1991 , vol. 21, # 3 p. 427 - 433
反应条件
acetic acid in N,N-dimethyl-formamide
T=80 - 140°C; 10 h; no temperature effects (80 - 140 deg C); regioselective alkylation (5-nitro-isomer); Product distributionMechanism;
参考文献
Rao, A. K. S. Bhujanga; Rao, C. Gundu; Singh, B. B.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1994 , # 17 p. 2399 - 2402
反应条件
acetic acid in N,N-dimethyl-formamide
T=80 - 140°C; 10 h; no temperature effects (80 - 140 deg C); regioselective alkylation (5-nitro-isomer); Product distributionMechanism;
参考文献
Rao, A. K. S. Bhujanga; Rao, C. Gundu; Singh, B. B.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1994 , # 17 p. 2399 - 2402
参考文献
McKillop, Alexander; Wright, Derek E.; Podmore, Michael L.; Chambers, Robert K.
Tetrahedron, 1983 , vol. 39, # 22 p. 3797 - 3800
