反应条件
1: piperidine; acetic acid / toluene / Inert atmosphere; Reflux 2: 3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide; triethylamine / 70 °C / Inert atmosphere 3: methanol / Inert atmosphere 4: sodium hydroxide / 1,4-dioxane; ethanol; water / Reflux; Inert atmosphere View Scheme
参考文献
Aguilar, Angelo; Zhou, Haibin; Chen, Jianfang; Liu, Liu; Bai, Longchuan; McEachern, Donna; Yang, Chao-Yie; Meagher, Jennifer; Stuckey, Jeanne; Wang, Shaomeng
Journal of Medicinal Chemistry, 2013 , vol. 56, # 7 p. 3048 - 3067