2,5-二甲氧基四氢呋喃合成路线 （共 286 条）
反应条件
in acetic acid
T=110 - 120°C; 1.5 h;
参考文献
Carpio; Galeazzi; Greenhouse; et al.
Canadian Journal of Chemistry, 1982 , vol. 60, # 18 p. 2295 - 2312
参考文献
Ciba-Geigy Corporation
Patent: US4176190 A1, 1979 ;
反应条件
trifluoroacetic acid
T=20°C; Condensation; 5 h;
参考文献
Banihashemi, Ahmad; Rahmatpour, Ali
Journal of Chemical Research - Part S, 1999 , # 6 p. 390 - 391
反应条件
in acetic acid
0.0833333 h; Heating;
参考文献
Ong Lee; Sylvester; Wasley
Journal of Heterocyclic Chemistry, 1983 , vol. 20, # 6 p. 1565 - 1569
反应条件
hydrogenchloride in water; toluene
pH=2 - 3; 48 h;
参考文献
Roszkowski, Piotr; Maurin, Jan K.; Czarnocki, Zbigniew
Synthesis, 2012 , vol. 2012, # 2 p. 241 - 246
反应条件
in acetic acid
1.5 h; Heating;
参考文献
Lancelot; Gazengel; Rault; Robba
Chemical and Pharmaceutical Bulletin, 1982 , vol. 30, # 5 p. 1674 - 1679
参考文献
Prunier, Herve; Rault, Sylvain; Lancelot, Jean-Charles; Robba, Max; Renard, Pierre; Delagrange, Philippe; Pfeiffer, Bruno; Caignard, Daniel-Henri; Misslin, Rene; Guardiola-Lemaitre, Beatrice; Hamon, Michel
Journal of Medicinal Chemistry, 1997 , vol. 40, # 12 p. 1808 - 1819
反应条件
acetic acid
4 h; Heating;
参考文献
Ilyn, Alexey P.; Trifilenkov, Andrey S.; Kuzovkova, Julia A.; Kutepov, Sergey A.; Nikitin, Alexandre V.; Ivachtchenko, Alexandre V.
Journal of Organic Chemistry, 2005 , vol. 70, # 4 p. 1478 - 1481
反应条件
1: in 1,4-dioxane
Reflux;
2: With hydrogenchloride in 1,4-dioxane; water
参考文献
NEOPHARM CO., LTD.
Patent: US2011/183983 A1, 2011 ;
Location in patent: Page/Page column 23 ;
反应条件
4-chloro pyridine hydrochloride in 1,4-dioxane
Reflux;
参考文献
Grande, Fedora; Brizzi, Antonella; Garofalo, Antonio; Aiello, Francesca
Tetrahedron, 2013 , vol. 69, # 47 p. 9951 - 9956
