反应条件
1: 78 percent / NEt3, Pd(OAc)2, tri-o-tolylphosphine / dimethylformamide / 24 h / Heating
2: 65 percent / NaBH4, 9 N HCl / tetrahydrofuran; aq. ethanol / 1.) pH 7, -35 deg C, 1 h, 2.) -20 deg C, overnight
3: 81 percent / 4.5 N HCl / 2.5 h / 100 °C
4: 100 percent / HCl gas / 0 - 5 °C
5: 84 percent / triethylamine, DCC / tetrahydrofuran / Ambient temperature
6: 67 percent / trifluoroacetic acid / CH2Cl2 / 0.67 h / 0 °C
7: 75 percent / DCC / CH2Cl2 / 1.) -20 deg C to 0 deg C, 3 h, 2.) 4 deg C, 36 h
8: ethanethiol, AlBr3 / CH2Cl2 / 24 h / Ambient temperature
9: DCC, DMAP, DMAP-TFA / CHCl3 / 16 h / Heating
View Scheme
参考文献
Chu; Negrete; Konopelski
Journal of Organic Chemistry, 1991 , vol. 56, # 16 p. 5196 - 5202
