L-3-(2-萘)-丙氨酸合成路线 （共 21 条）
反应条件
acetic anhydride in sodium hydroxide
参考文献
Syntex Inc.
Patent: US4341767 A1, 1982 ;
反应条件
triethylamine in 1,4-dioxane; water
参考文献
James Black Foundation Limited
Patent: US5486597 A1, 1996 ;
反应条件
sodium hydroxide in 1,4-dioxane pH 10;
参考文献
Rodriguez; Bernad; Galas; Lignon; Laur; Aumelas; Martinez
European Journal of Medicinal Chemistry, 1991 , vol. 26, # 3 p. 245 - 253
反应条件
triethylamine in 1,4-dioxane; water
参考文献
James Black Foundation Limited
Patent: US5486597 A1, 1996 ;
反应条件
sodium hydroxide in 1,4-dioxane pH 10;
参考文献
Rodriguez; Bernad; Galas; Lignon; Laur; Aumelas; Martinez
European Journal of Medicinal Chemistry, 1991 , vol. 26, # 3 p. 245 - 253
反应条件
1: SOCl2 / 3 h / Heating 2: 16.5 g / iPr2NEt / CHCl3 / 12 h / 20 °C View Scheme
参考文献
Niida, Ayumu; Tanigaki, Hiroaki; Inokuchi, Eriko; Sasaki, Yoshikazu; Oishi, Shinya; Ohno, Hiroaki; Tamamura, Hirokazu; Wang, Zixuan; Peiper, Stephen C.; Kitaura, Kazuo; Otaka, Akira; Fujii, Nobutaka
Journal of Organic Chemistry, 2006 , vol. 71, # 10 p. 3942 - 3951
反应条件
1: (S)-α,α-diphenylprolinol - n-butylboronic acid catalyst, catecholborane / CH2Cl2 / 1.7 h / -23 °C
2: 84 percent / NaN3, NaOH, H2O / 1,2-dimethoxy-ethane / 24 h / 23 °C
3: 88 percent / H2 / 10percent Pd/C / ethyl acetate / 13 h / 760 Torr
View Scheme
参考文献
Corey, E. J.; Link, John O.
Journal of the American Chemical Society, 1992 , vol. 114, # 5 p. 1906 - 1908
反应条件
1: 84 percent / NaN3, NaOH, H2O / 1,2-dimethoxy-ethane / 24 h / 23 °C
2: 88 percent / H2 / 10percent Pd/C / ethyl acetate / 13 h / 760 Torr
View Scheme
参考文献
Corey, E. J.; Link, John O.
Journal of the American Chemical Society, 1992 , vol. 114, # 5 p. 1906 - 1908
反应条件
oxygen; D-amino acid oxidase (M213G mutant, Rhodotorula gracilis) in phosphate buffer
T=25°C; pH=8.5; 0.416667 h; Enzymatic reaction;
参考文献
Caligiuri, Antonio; D'Arrigo, Paola; Rosini, Elena; Tessaro, Davide; Molla, Gianluca; Servi, Stefano; Pollegioni, Loredano
Advanced Synthesis and Catalysis, 2006 , vol. 348, # 15 p. 2183 - 2190
反应条件
1: 70 percent / conc. HCl / H2O; ethanol / 12 h / Heating
2: O2 / D-amino acid oxidase (M213G mutant, Rhodotorula gracilis) / aq. phosphate buffer / 0.42 h / 25 °C / pH 8.5 / Enzymatic reaction
View Scheme
参考文献
Caligiuri, Antonio; D'Arrigo, Paola; Rosini, Elena; Tessaro, Davide; Molla, Gianluca; Servi, Stefano; Pollegioni, Loredano
Advanced Synthesis and Catalysis, 2006 , vol. 348, # 15 p. 2183 - 2190
