5-硝基苯并呋喃-2-羧酸乙酯合成路线 （共 19 条）
反应条件
1: ethanolic KOH-solution 2: copper; quinoline View Scheme
参考文献
Tanaka
Nippon Kagaku Zasshi, 1952 , vol. 73, p. 282,285
Chem.Abstr., 1953 , p. 9957
反应条件
ammonia in ethanol T=20°C; Aminolysis; 24 h;
参考文献
Coates, Philippa A.; Grundt, Peter; Robinson, Emma S.J.; Nutt, David J.; Tyacke, Robin; Hudson, Alan L.; Lewis, John W.; Husbands, Stephen M.
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 6 p. 605 - 607
反应条件
1: 93 percent / H2 / Raney Ni / methanol / 27 h / 28 °C 2: 27 percent / K2CO3 / butan-1-ol / 48 h / Heating 3: K2CO3; Et3N / acetonitrile / 12 h / Heating 4: KOH / methanol / 3 h / Heating 5: 72 percent / 1-methyl-2-chloropyridinium iodide; Et2NiPr; NH3(g) / 1-methyl-pyrrolidin-2-one View Scheme
参考文献
ALEMBIC PHARMACEUTICALS LIMITED; JAYARAMAN, Venkat Raman; RATHOD, Dhiraj; VOHRA, Irfan; BHUJADE, Vinayak; MODI, Viral; GANDHI, Ojas; BUDH, Mayur
Patent: WO2013/153492 A2, 2013 ;
反应条件
water; sodium hydroxide in methanol 0.5 h; Heating;
参考文献
Aboraia, Ahmed S.; Yee, Sook Wah; Gomaa, Mohamed Sayed; Shah, Nikhil; Robotham, Anna C.; Makowski, Bart; Prosser, David; Brancale, Andrea; Jones, Glenville; Simons, Claire
Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 14 p. 4939 - 4946
参考文献
Tanaka
Nippon Kagaku Zasshi, 1952 , vol. 73, p. 282,285
Chem.Abstr., 1953 , p. 9957
Full Text Show Details
Andrisano et al.
Gazzetta Chimica Italiana, 1956 , vol. 86, p. 1257,1267
反应条件
1: 93 percent / H2 / Raney Ni / methanol / 27 h / 28 °C 2: 27 percent / K2CO3 / butan-1-ol / 48 h / Heating 3: K2CO3; Et3N / acetonitrile / 12 h / Heating View Scheme
参考文献
Heinrich, Timo; Boettcher, Henning; Gericke, Rolf; Bartoszyk, Gerd D.; Anzali, Soheila; Seyfried, Christoph A.; Greiner, Hartmut E.; Van Amsterdam, Christoph
Journal of Medicinal Chemistry, 2004 , vol. 47, # 19 p. 4684 - 4692
反应条件
1: 93 percent / H2 / Raney Ni / methanol / 27 h / 28 °C 2: 27 percent / K2CO3 / butan-1-ol / 48 h / Heating 3: K2CO3; Et3N / acetonitrile / 12 h / Heating 4: KOH / methanol / 3 h / Heating View Scheme
参考文献
Heinrich, Timo; Boettcher, Henning; Gericke, Rolf; Bartoszyk, Gerd D.; Anzali, Soheila; Seyfried, Christoph A.; Greiner, Hartmut E.; Van Amsterdam, Christoph
Journal of Medicinal Chemistry, 2004 , vol. 47, # 19 p. 4684 - 4692
反应条件
palladium 10 on activated carbon; hydrogen in ethyl acetate T=33 - 38°C; P=3000.3 - 3750.38 Torr;
参考文献
ALEMBIC PHARMACEUTICALS LIMITED; JAYARAMAN, Venkat Raman; RATHOD, Dhiraj; VOHRA, Irfan; BHUJADE, Vinayak; MODI, Viral; GANDHI, Ojas; BUDH, Mayur
Patent: WO2013/153492 A2, 2013 ;
Location in patent: Page/Page column 23 ;
反应条件
1: ethanolic KOH-solution
2: hydrogen chloride
View Scheme
参考文献
Andrisano et al.
Gazzetta Chimica Italiana, 1956 , vol. 86, p. 1257,1267
