N-Boc-L-脯氨醇合成路线 （共 100 条）
反应条件
triethylamine in ethyl acetate T=0 - 20°C; 11.5 h;
参考文献
Merck Sharp and Dohme, Ltd.
Patent: US5854268 A1, 1998 ;
反应条件
borane-THF T=0°C; 1 h;
参考文献
Zhang, Honglu; Ni, Yi-Ke; Zhao, Gang; Ding, Yu
European Journal of Organic Chemistry, 2003 , # 10 p. 1918 - 1922
反应条件
lithium borohydride in tetrahydrofuran T=20°C;
参考文献
Diaba, Faiza; Ricou, Eva; Bonjoch, Josep
Tetrahedron Asymmetry, 2006 , vol. 17, # 9 p. 1437 - 1443
反应条件
sodium tetrahydroborate in ethanol 0.75 h;
参考文献
Reed, Peter E.; Katzenellenbogen, John A.
Journal of Organic Chemistry, 1991 , vol. 56, # 8 p. 2624 - 2634
反应条件
triethylamine in water; ethyl acetate
参考文献
Meiji Seika Kaisha, Ltd.; Bayer Aktiengesellschaft
Patent: US6329338 B1, 2001 ;
反应条件
1: With sodium borohydride; lithium chloride in tetrahydrofuran; ethanol T=0°C; 0.416667 h; 2: (R)-tert-butyl 2-(methoxy(methyl)carbamoyl)pyrrolidine-1-carboxylate T=0 - 20°C; 18 h; 3: With acetic acid in water
参考文献
US2004/167128 A1, ;
Page 103 ;
反应条件
1: lithium aluminium hydride / tetrahydrofuran / 0 - 25 °C 2: 39.1 g / tetrahydrofuran / 20 °C View Scheme
参考文献
Organic Letters, , vol. 9, # 19 p. 3717 - 3720
反应条件
sodium borohydride; sodium hydrogencarbonate; triethylamine; silica gel in tetrahydrofuran
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=0°C; 16 h;
参考文献
Hiroi; Abe
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 3 p. 616 - 621
反应条件
sodium tetrahydroborate in ethanol T=20°C;
参考文献
Ragnarsson, Ulf; Grehn, Leif; Monteiro, Luis S.; Maia, Hernani L. S.
Synlett, 2003 , # 15 p. 2386 - 2388
